Titanium biomaterials are widely used in the medical field due to their biocompatibility and excellent corrosion and mechanical resistance. However, these materials have no antibacterial properties. To obtain an antibacterial active surface, a nanostructure of Ti6Al4V alloy was created. This specific nanostructure contained nanotubes and micro-cavities and was used as a substrate for silver anchoring. The electrochemical approach to silver reduction was studied. It is a common approach for silver deposition and in this work, inhomogeneities in the nanostructure were used as a preferential area for silver localisation. The galvanostatic regimen of deposition allowed for a technically quantitative process and the required silver placement. The experimental conditions used enabled testing and silver dissolution rate evaluation within a reasonable time span. Based on the corrosion and analytical results (EDS, XPS and ICP-MS), a two-phase silver release mechanism was confirmed. The openings of the individual nanotubes were filled with silver nanoparticles, whose release was relatively fast. By contrast, the silver anchored inside the cavities allowed the silver to release gradually. Antibacterial efficiency against Staphylococcus aureus and Escherichia coli was successfully demonstrated. Cytotoxicity testing with murine fibroblasts showed cell metabolic activity far above the normative limit of 70%.

钛生物材料具有生物相容性，优异的耐腐蚀性和机械强度，因此在医学领域得到了广泛的应用。但是，这些材料没有抗菌性能。为了获得抗菌活性表面，创建了Ti6Al4V合金的纳米结构。这种特定的纳米结构包含纳米管和微腔，并被用作银锚固的基底。研究了电化学还原银的方法。这是沉积银的一种常用方法，在这项工作中，纳米结构中的不均匀性被用作银定位的优先区域。恒电流沉积方案允许进行技术上定量的过程和所需的银放置。使用的实验条件能够在合理的时间范围内进行测试和评估银的溶解速度。根据腐蚀和分析结果（EDS，XPS和ICP-MS），确定了两相银释放机理。单个纳米管的开口充满了银纳米颗粒，其释放速度相对较快。相反，锚定在腔体内的银使银逐渐释放。抗菌功效金黄色葡萄球菌和大肠杆菌被成功证明。用鼠成纤维细胞进行的细胞毒性试验表明，细胞代谢活性远高于标准极限的70％。