Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on insights gleaned from almost a quarter century of research, it is obvious that deregulation of spatio-temporally controlled signaling pathways play instrumental role in development and progression of colorectal cancer. High-throughput technologies have helped to develop a sharper and broader understanding of the wide ranging signal transduction cascades which also contribute to development of drug resistance, loss of apoptosis and, ultimately, of metastasis. In this review, we have set the spotlight on role of JAK/STAT, TGF/SMAD, Notch, WNT/β-Catenin, SHH/GLI and p53 pathways in the development and progression of colorectal cancer. We have also highlighted recent reports on TRAIL-mediated pathways and molecularly distinct voltage-gated sodium channels in colorectal cancer.

大肠癌是多方面的疾病，在治疗上具有挑战性。基于近四分之一个世纪的研究中得出的见解，很明显，时空控制的信号通路的失调在结直肠癌的发生和发展中起着重要的作用。高通量技术帮助人们对广泛的信号转导级联反应有了更清晰，更广泛的了解，这也有助于耐药性的发展，细胞凋亡的丧失以及最终的转移。在这篇综述中，我们着重探讨了JAK / STAT，TGF / SMAD，Notch，WNT /β-Catenin，SHH / GLI和p53通路在大肠癌发展和进程中的作用。