A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis.,Neuropsychopharmacology

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A novel GPR55-mediated satiety signal in the oval Bed Nucleus of the Stria Terminalis.
Neuropsychopharmacology ( IF 6.6 ) Pub Date : 2019-01-07 , DOI: 10.1038/s41386-018-0309-0
E R Hawken ₁ , C P Normandeau ₁ , J Gardner Gregory ₁ , B Cécyre ₂ , J-F Bouchard ₂ , K Mackie ₃ , É C Dumont ₁

Affiliation

Nestled within feeding circuits, the oval (ov) region of the Bed Nucleus of the Stria Terminalis (BNST) may be critical for monitoring energy balance through changes in synaptic strength. Here we report that bidirectional plasticity at ovBNST GABA synapses was tightly linked to the caloric state of male rats, seesawing between long-term potentiation (iLTP, fed) and depression (iLTD, food restricted). L-α-lysophosphatidylinositol (LPI) acting on GPR55 receptors and 2-arachidonoylglycerol (2-AG) through CB1R were respectively responsible for fed (iLTP) and food restricted (iLTD) states. Thus, we have characterized a potential gating mechanism within the ovBNST that may signal metabolic state within the rat brain feeding circuitry.

中文翻译：

在终端纹状体的椭圆形床核中有一个新的GPR55介导的饱食感信号。

坐落在进食回路中，终端纹状体床核（BNST）的椭圆形（ov）区域对于通过突触强度变化监测能量平衡可能至关重要。在这里，我们报道在ovBNST GABA突触处的双向可塑性与雄性大鼠的热量状态紧密相关，长期增强（iLTP，进食）和抑郁（iLTD，食物受限制）之间存在倾斜。通过CB1R作用于GPR55受体的L-α-溶血磷脂酰肌醇（LPI）和2-花生四烯酰甘油（2-AG）分别负责进食（iLTP）和食物受限（iLTD）状态。因此，我们已经表征了ovBNST中的一种潜在的门控机制，该机制可能表明了大鼠脑饲喂电路中的代谢状态。

更新日期：2019-01-26

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