A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light,ACS Central Science

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A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light
ACS Central Science ( IF 12.7 ) Pub Date : 2019-01-07 00:00:00 , DOI: 10.1021/acscentsci.8b00728
Kaid C. Harper ₁ , Eric G. Moschetta ₁ , Shailendra V. Bordawekar ₁ , Steven J. Wittenberger ₁

Affiliation

Visible-light-promoted organic reactions can offer increased reactivity and selectivity via unique reaction pathways to address a multitude of practical synthetic problems, yet few practical solutions exist to employ these reactions for multikilogram production. We have developed a simple and versatile continuous stirred tank reactor (CSTR) equipped with a high-intensity laser to drive photochemical reactions at unprecedented rates in continuous flow, achieving kg/day throughput using a 100 mL reactor. Our approach to flow reactor design uses the Beer–Lambert law as a guideline to optimize catalyst concentration and reactor depth for maximum throughput. This laser CSTR platform coupled with the rationale for design can be applied to a breadth of photochemical reactions.

中文翻译：

激光驱动流化学平台，用于放大可见光下的光化学反应

可见光促进的有机反应可通过独特的反应途径提供更高的反应性和选择性，从而解决了许多实际的合成问题，但很少有实际的解决方案可将这些反应用于生产多千克的产品。我们开发了一种简单且通用的连续搅拌釜式反应器（CSTR），该反应器配有高强度激光，以前所未有的速率连续流驱动光化学反应，使用100 mL反应器可达到kg / day的产量。我们的流式反应器设计方法以Beer–Lambert法则为准则，以优化催化剂浓度和反应器深度，以实现最大产量。该激光CSTR平台与设计原理相结合，可应用于多种光化学反应。

更新日期：2019-01-07

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