Mesial Temporal Lobe Epilepsy (mTLE) characterized by progressive development of complex partial seizures originating from the hippocampus is the most prevalent and refractory type of epilepsy. One of the remarkable features of mTLE is the rhythmic pattern of occurrence of spontaneous seizures, implying a dependence on the endogenous clock system for seizure threshold. Conversely, circadian rhythms are affected by epilepsy too. Comprehending how the circadian system and seizures interact with each other is essential for understanding the pathophysiology of epilepsy as well as for developing innovative therapies that are efficacious for better seizure control. In this review, we confer how the temporal dysregulation of the circadian clock in the hippocampus combined with multiple uncoupled oscillators could lead to periodic seizure occurrences and comorbidities. Unraveling these associations with additional research would help in developing chronotherapy for mTLE, based on the chronobiology of spontaneous seizures. Notably, differential dosing of antiepileptic drugs over the circadian period and/or strategies that resynchronize biological rhythms may substantially improve the management of seizures in mTLE patients.

中文翻译：

---

边缘性癫痫的年代生物学：内侧颞叶癫痫的时序治疗的潜在机制和前景。

以颞部复杂性癫痫发作为特征的中颞叶癫痫病（mTLE）是癫痫最普遍和最难治的类型。mTLE的显着特征之一是自发性癫痫发作的节奏模式，这意味着癫痫发作阈值依赖于内源性时钟系统。相反，昼夜节律也受癫痫病的影响。了解昼夜节律系统和癫痫发作如何相互作用对于理解癫痫的病理生理以及开发有效控制癫痫发作的创新疗法至关重要。在这篇评论中，我们提出海马生物钟的时间失调与多个未耦合的振子相结合如何导致周期性癫痫发作和合并症。基于自发性癫痫发作的年代生物学，通过进一步的研究来阐明这些关联将有助于开发mTLE的年代疗法。值得注意的是，在昼夜节律期间不同剂量的抗癫痫药和/或使生物节律重新同步的策略可能会大大改善mTLE患者的癫痫发作管理。