3D Printing of Poloxamer 407 Nanogel Discs and Their Applications in Adjuvant Ovarian Cancer Therapy.,Molecular Pharmaceutics

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3D Printing of Poloxamer 407 Nanogel Discs and Their Applications in Adjuvant Ovarian Cancer Therapy.
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2019-01-04 00:00:00 , DOI: 10.1021/acs.molpharmaceut.8b00836
Hyunah Cho ₁ , Udayabhanu Jammalamadaka ₂ , Karthik Tappa ₂ , Christopher Egbulefu ₂ , Julie Prior ₂ , Rui Tang ₂ , Samuel Achilefu ₂

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Nanogels are attractive biocompatible materials that enable local delivery of multiple drugs. In this study, we demonstrated that 3D printing technology could be used to precisely construct nanogel discs carrying paclitaxel and rapamycin. 3D-printed nanogel disc rounds (12 mm diameter × 1 mm thickness) carrying paclitaxel and rapamycin evaded premature gelation during storage and the initial burst release of the drugs in the dissolution medium. In vivo 3D-printed nanogel discs permitted successful intraperitoneal delivery of paclitaxel and rapamycin in ES-2-luc ovarian-cancer-bearing xenograft mice. They were also shown to be therapeutically effective and capable of preventing postsurgical peritoneal adhesions in the treated xenograft mice.

中文翻译：

Poloxamer 407纳米凝胶片的3D打印及其在卵巢癌辅助治疗中的应用。

纳米凝胶是具有吸引力的生物相容性材料，可实现多种药物的局部递送。在这项研究中，我们证明了3D打印技术可用于精确构建携带紫杉醇和雷帕霉素的纳米凝胶盘。携带紫杉醇和雷帕霉素的3D打印纳米凝胶圆盘（直径12毫米×1毫米厚）在储存期间以及药物在溶出介质中的初始爆发释放过程中避免了过早的凝胶化。体内3D打印的纳米凝胶光盘可在ES-2-luc卵巢癌的异种移植小鼠中成功地腹膜内递送紫杉醇和雷帕霉素。还显示它们在治疗上有效，并且能够在所治疗的异种移植小鼠中预防手术后腹膜粘连。

更新日期：2019-01-04

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