A novel and efficient synthesis of N-substituted dipyrrolo[1,2-a:2′,1′-c]pyrazine derivatives has been developed. The synthetic strategy relies on the synthesis of 4′,5′-dihydro-1H,3′H-2,2′-bipyrrole, followed by the reaction with propargyl bromide. Various substituents were introduced to the alkyne functionality using the Sonogashira coupling reaction. Aromatization of the dihydropyrrole ring followed by an intramolecular cyclization reaction between the alkyne functionality and the pyrrole nitrogen atom was catalyzed by Pd/C at high temperature to furnish the desired dipyrrolo-pyrazine skeleton.

中文翻译：

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通过Pd / C催化的N-炔丙基吡咯烷基-吡咯衍生物的环化反应合成吡咯并吡咯并吡嗪

已经开发出新颖且有效的合成N-取代的二吡咯并[1,2- a：2'，1'- c ]吡嗪衍生物。合成策略依赖于合成4'，5'-二氢ħ，3' ħ -2,2'-二吡咯，接着用炔丙基溴反应。使用Sonogashira偶联反应将各种取代基引入炔烃官能团。Pd / C在高温下催化二氢吡咯环芳香化，然后在炔烃官能团和吡咯氮原子之间进行分子内环化反应，以提供所需的二吡咯并吡嗪骨架。