DNA Quadruple Helices in Nanotechnology.,Chemical Reviews

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DNA Quadruple Helices in Nanotechnology.
Chemical Reviews ( IF 51.4 ) Pub Date : 2019-01-03 , DOI: 10.1021/acs.chemrev.8b00629
Jean-Louis Mergny _{1,

2,

3} , Dipankar Sen _{4,

5}

Affiliation

DNA has played an early and powerful role in the development of bottom-up nanotechnologies, not least because of DNA's precise, predictable, and controllable properties of assembly on the nanometer scale. Watson-Crick complementarity has been used to build complex 2D and 3D architectures and design a number of nanometer-scale systems for molecular computing, transport, motors, and biosensing applications. Most of such devices are built with classical B-DNA helices and involve classical A-T/U and G-C base pairs. However, in addition to the above components underlying the iconic double helix, a number of alternative pairing schemes of nucleobases are known. This review focuses on two of these noncanonical classes of DNA helices: G-quadruplexes and the i-motif. The unique properties of these two classes of DNA helix have been utilized toward some remarkable constructions and applications: G-wires; nanostructures such as DNA origami; reconfigurable structures and nanodevices; the formation and utilization of hemin-utilizing DNAzymes, capable of generating varied outputs from biosensing nanostructures; composite nanostructures made up of DNA as well as inorganic materials; and the construction of nanocarriers that show promise for the therapeutics of diseases.

中文翻译：

纳米技术中的DNA四重螺旋。

DNA在自下而上的纳米技术的发展中起着早期而强大的作用，这不仅是因为DNA在纳米规模上具有精确，可预测和可控制的组装特性。Watson-Crick的互补性已用于构建复杂的2D和3D架构，并设计了许多用于分子计算，运输，电机和生物传感应用的纳米级系统。大多数此类设备都是用经典的B-DNA螺旋构建的，并且涉及经典的AT / U和GC碱基对。然而，除了标志性双螺旋下面的上述组分外，许多已知的碱基的替代配对方案也是已知的。这篇综述着重介绍了这些非经典的DNA螺旋中的两种：G-四链体和i-基序。这两类DNA螺旋的独特性质已被用于一些非凡的结构和应用中：纳米结构，例如DNA折纸；可重构结构和纳米器件；利用血红素的DNA酶的形成和利用，能够从生物传感纳米结构产生各种输出；由DNA和无机材料组成的复合纳米结构；纳米载体的构建显示出对疾病治疗的希望。

更新日期：2019-01-03

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