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High levels of antibodies to citrullinated α-enolase peptide-1 (CEP-1) identify erosions and interstitial lung disease (ILD) in a Chinese rheumatoid arthritis cohort.
Clinical Immunology ( IF 4.5 ) Pub Date : 2019-01-03 , DOI: 10.1016/j.clim.2019.01.001 Yudong Liu 1 , Chenxi Liu 2 , Liubing Li 2 , Fengchun Zhang 2 , Yongzhe Li 3 , Shulan Zhang 2
Clinical Immunology ( IF 4.5 ) Pub Date : 2019-01-03 , DOI: 10.1016/j.clim.2019.01.001 Yudong Liu 1 , Chenxi Liu 2 , Liubing Li 2 , Fengchun Zhang 2 , Yongzhe Li 3 , Shulan Zhang 2
Affiliation
We evaluated the clinical performance of anti-CEP-1 in a Chinese rheumatoid arthritis (RA) cohort. A total of 264 subjects were tested, including 101 RA patients, 38 juvenile idiopathic arthritis (JIA) patients, 46 disease control (DC) and 79 healthy controls (HC). The presence of anti-CEP-1 in patients with RA, JIA, DCs and HC were 61.4%, 13.2%, 15.2% and 5.1%, respectively. Anti-CCP2 demonstrated the highest positive likelihood ratio of 10.11 in the diagnosis of RA, followed by RF (8.88) and anti-CEP-1 (5.82). Anti-CEP-1 positive RA patients displayed significantly higher DAS28 compared to anti-CEP-1 negative RA patients (p = .045). Significant associations were identified between anti-CEP-1 and joint erosions at anti-CEP-1 value of >124.78 U/ml (p = .0026) and between anti-CEP-1 and ILD at anti-CEP-1 value of >185.91 U/ml (p = .0222). Our findings indicate that anti-CEP-1 may not be able to replace anti-CCP2 for routine diagnosis for RA, but they may be helpful for subtyping of the disease.
更新日期：2019-01-03
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