Advanced drug delivery systems and artificial skin grafts for skin wound healing.,Advanced Drug Delivery Reviews

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Advanced drug delivery systems and artificial skin grafts for skin wound healing.
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2018-12-31 , DOI: 10.1016/j.addr.2018.12.014
Hye Sung Kim ₁ , Xiaoyan Sun ₂ , Jung-Hwan Lee ₃ , Hae-Won Kim ₄ , Xiaobing Fu ₂ , Kam W Leong ₅

Affiliation

Cutaneous injuries, especially chronic wounds, burns, and skin wound infection, require painstakingly long-term treatment with an immense financial burden to healthcare systems worldwide. However, clinical management of chronic wounds remains unsatisfactory in many cases. Various strategies including growth factor and gene delivery as well as cell therapy have been used to enhance the healing of non-healing wounds. Drug delivery systems across the nano, micro, and macroscales can extend half-life, improve bioavailability, optimize pharmacokinetics, and decrease dosing frequency of drugs and genes. Replacement of the damaged skin tissue with substitutes comprising cell-laden scaffold can also restore the barrier and regulatory functions of skin at the wound site. This review covers comprehensively the advanced treatment strategies to improve the quality of wound healing.

中文翻译：

先进的药物输送系统和人造皮肤移植物可用于皮肤伤口愈合。

皮肤损伤，特别是慢性伤口，烧伤和皮肤伤口感染，需要艰苦的长期治疗，这给全世界的医疗系统带来了沉重的经济负担。然而，在许多情况下，慢性伤口的临床管理仍然不能令人满意。包括生长因子和基因递送以及细胞疗法在内的各种策略已被用于增强非愈合伤口的愈合。跨纳米，微米和宏观尺度的药物输送系统可以延长半衰期，提高生物利用度，优化药代动力学，并降低药物和基因的给药频率。用包含充满细胞的支架的替代物替换受损的皮肤组织也可以在伤口部位恢复皮肤的屏障和调节功能。

更新日期：2019-11-18

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