An acid-promoted multicomponent reaction for the direct C(sp³)N bond formation was achieved through intermolecular allylic amidation in a one-pot operation to synthesize 7-acetamido tetrahydroindole derivatives from simple and readily available arylglyoxal monohydrates, acetonitriles, and enamines of 5,5-dimethyl-1,3-cyclohexadione (dimedone) has been developed. Here acetonitrile acts both as solvent and reagent. These tetahydroindole derivatives are formed through domino condensation of the enamines and arylglyoxals followed by annulation and allylic amidation.

中文翻译：

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酸促进多组分烯丙基酰胺化成7-乙酰氨基四氢吲哚衍生物

通过一分子操作中的分子间烯丙基酰胺化反应，可以从简单易得的芳基乙二醛一水合物，乙腈和5种烯胺合成7-乙酰氨基四氢吲哚衍生物，从而实现直接C（sp ³）N键形成酸的多组分反应。已经开发了1-5-二甲基-1，3-环己二酮（二甲酮）。在此乙腈既充当溶剂又充当试剂。这些四氢吲哚衍生物是通过烯胺和芳基乙二醛的多米诺缩合反应，然后进行环化和烯丙基酰胺化反应而形成的。