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Diastereoselective scalable synthesis of 2,6-trans-Piperidines using an aza-Michael reaction
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-12-26 , DOI: 10.1016/j.tetlet.2018.12.061
Somenath Chowdhury , Jianmin Mao , Jacek Martynow , He Zhao , Erin Duffy , Yusheng Wu , Vinay Thakur , Gopal Sirasani , Yuanqing Tang , Florine Collin , Sandra Sinishtaj , Ashoke Bhattacharjee

Highly efficient substrate and reagent controlled stereoselective synthesis of 2,6-trans-piperidine derivative (1) using an aza-Michael reaction is reported. This method was utilized to synthesize a variety of trans-piperidines on hundred-gram scales.



中文翻译:

使用氮杂-迈克尔反应的非对映选择性可扩展合成2,6-反式-哌啶

报道了使用氮杂-迈克尔反应的高效的底物和试剂控制的2,6-反式-哌啶衍生物(1)的立体选择性合成。该方法用于以百克规模合成各种反式哌啶。

更新日期:2018-12-26
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