Highly efficient substrate and reagent controlled stereoselective synthesis of 2,6-trans-piperidine derivative (1) using an aza-Michael reaction is reported. This method was utilized to synthesize a variety of trans-piperidines on hundred-gram scales.

中文翻译：

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使用氮杂-迈克尔反应的非对映选择性可扩展合成2,6-反式-哌啶

报道了使用氮杂-迈克尔反应的高效的底物和试剂控制的2，6-反式-哌啶衍生物（1）的立体选择性合成。该方法用于以百克规模合成各种反式哌啶。