BACKGROUND Determinants and the extent of dry skin in healthy middle-aged and elderly populations have not been well established. OBJECTIVE We aimed to identify the prevalence and determinants for generalized dry skin (GDS) and localized dry skin (LDS) within a large prospective population-based cohort of middle-aged and elderly individuals of the Rotterdam Study. METHODS Dry skin was physician-graded as none, localized, or generalized. For GDS and LDS, separate multivariable logistic regression analyses were performed to search for association with participant characteristics, lifestyle factors, environmental factors, several comorbidities, and drug exposure. RESULTS Among the 5547 eligible participants, 60% had dry skin, of whom a fifth had GDS. Age, female sex, skin color, body mass index, outside temperature, eczema, and chemotherapy in the past were significant determinants for both GDS and LDS. Smoking, the use of statins and diuretics, poorer self-perceived health, and several dermatologic conditions increased the likelihood of having GDS only. Daily cream use was associated with less LDS. LIMITATIONS Interobserver variability and residual confounding could have influenced our results. Because of our cross-sectional design, we could not infer causality. CONCLUSION We identified factors significantly associated with dry skin in a general middle-aged and elderly population, with health parameters more strongly associated with GDS.

中文翻译：

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中老年人群皮肤角质干燥的发生率和决定因素：一项横断面研究。

背景技术健康的中老年人群的决定因素和皮肤干燥程度尚未得到很好的确定。目的我们的目的是在鹿特丹研究的一个以人群为基础的大型前瞻性队列研究中，确定广义干性皮肤（GDS）和局部性干性皮肤（LDS）的患病率和决定因素。方法干性皮肤经医师分级为无，局部或全身性。对于GDS和LDS，分别进行了多变量logistic回归分析，以寻找与参与者特征，生活方式因素，环境因素，多种合并症和药物暴露之间的关系。结果在5547名合格参与者中，有60％患有皮肤干燥，其中五分之一患有GDS。年龄，女性，肤色，体重指数，外界温度，湿疹，过去的化学疗法和化学疗法是决定GDS和LDS的重要因素。吸烟，使用他汀类药物和利尿剂，自我感觉较差的健康状况以及几种皮肤病学状况增加了仅服用GDS的可能性。每天使用面霜与较少的LDS有关。局限性观察者之间的差异和残留混杂可能影响了我们的结果。由于我们的横截面设计，我们无法推断因果关系。结论我们确定了与一般中老年人群中皮肤干燥明显相关的因素，其健康参数与GDS的相关性更强。每天使用面霜与较少的LDS有关。局限性观察者之间的差异和残留混杂可能影响了我们的结果。由于我们的横截面设计，我们无法推断因果关系。结论我们确定了与一般中老年人群中皮肤干燥明显相关的因素，其健康参数与GDS的相关性更强。每天使用面霜与较少的LDS有关。局限性观察者之间的差异和残留混杂可能影响了我们的结果。由于我们的横截面设计，我们无法推断因果关系。结论我们确定了与一般中老年人群中皮肤干燥明显相关的因素，其健康参数与GDS的相关性更强。