The mechanisms of the pathogenesis of epilepsy remain unclear. Recent research shows that the inflammatory process occurring in the brain may be a common and critical mechanism of seizures. Chitinase-3-like protein 1 (CHI3L1 or YKL-40) is a newly discovered inflammatory factor. We aimed to evaluate the role of YKL-40 as a biomarker for epilepsy. 124 subjects were classified as control group (n = 23), new-diagnosis epilepsy group (NDE, n = 34), drug responsive epilepsy group (DPE, n = 37), and drug-resistant epilepsy group (DRE, n = 30) YKL-40 was measured by ELISA in serum and cerebrospinal fluid (CSF). The concentrations of serum and CSF YKL-40 and its diagnostic accuracy for epilepsy were analysed. Patients with DRE had higher concentrations of YKL-40 in serum and CSF, while patients with NDE and DPE had increased YKL-40 levels in CSF but not serum in comparison with control. Moreover, serum and CSF YKL-40 provide high diagnostic accuracy for DRE. YKL-40 may play a possible pathogenic role in epilepsy. YKL-40 may represent a potential biomarker of brain inflammation in patients with DRE.

中文翻译：

---

几丁质酶3样蛋白1可能是耐药性癫痫患者的潜在生物标志物。

癫痫的发病机理尚不清楚。最近的研究表明，大脑中发生的炎症过程可能是癫痫发作的常见和关键机制。几丁质酶3样蛋白1（CHI3L1或YKL-40）是一种新发现的炎症因子。我们旨在评估YKL-40作为癫痫的生物标志物的作用。将124名受试者分为对照组（n = 23），新诊断性癫痫组（NDE，n = 34），药物反应性癫痫组（DPE，n = 37）和耐药性癫痫组（DRE，n = 30） ）通过ELISA在血清和脑脊髓液（CSF）中测量YKL-40。分析了血清和脑脊液YKL-40的浓度及其对癫痫的诊断准确性。DRE患者的血清和脑脊液中YKL-40的浓度较高，与对照组相比，NDE和DPE患者的CSF中YKL-40水平升高，但血清中升高。此外，血清和CSF YKL-40为DRE提供了很高的诊断准确性。YKL-40可能在癫痫病中发挥可能的致病作用。YKL-40可能代表DRE患者脑部炎症的潜在生物标志物。