当前位置: X-MOL 学术Genet. Med. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Estimating the burden and economic impact of pediatric genetic disease.
Genetics in Medicine ( IF 6.6 ) Pub Date : 2018-12-20 , DOI: 10.1038/s41436-018-0398-5
Nina Gonzaludo 1 , John W Belmont 1 , Vladimir G Gainullin 1 , Ryan J Taft 1
Affiliation  

PURPOSE To identify the economic impact of pediatric patients with clinical indications of genetic disease (GD) on the US health-care system. METHODS Using the 2012 Kids' Inpatient Database, we identified pediatric inpatient discharges with International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes linked to genetic disease, including well-established genetic disorders, neurological diseases, birth defects, and other physiological or functional abnormalities with a genetic basis. Cohort characteristics and health-care utilization measures were analyzed. Discharges with a GD-associated primary diagnosis were used to estimate the minimum burden; discharges with GD-associated primary or secondary codes established the maximum burden. RESULTS Of 5.85 million weighted discharges, 2.6-14% included GD-associated ICD-9-CM codes. For these discharges, mean total costs were $16,000-77,000 higher (P < 0.0001) in neonates and $12,000-17,000 higher (P < 0.0001) in pediatric patients compared with background, corresponding to significantly higher total charges and lengths of stay. Aggregate total charges for suspected GD accounted for $14 to $57 billion (11-46%) of the "national bill" for pediatric patients in 2012. CONCLUSION Pediatric inpatients with diagnostic codes linked to genetic disease have a significant and disproportionate impact on resources and costs in the US health-care system.

中文翻译:

估计儿科遗传病的负担和经济影响。

目的 确定有遗传病 (GD) 临床指征的儿科患者对美国医疗保健系统的经济影响。方法 使用 2012 年儿童住院患者数据库,我们确定了与遗传疾病相关的国际疾病分类、第九修订、临床修改 (ICD-9-CM) 代码的儿科住院患者出院,包括公认的遗传疾病、神经系统疾病、出生缺陷,以及其他具有遗传基础的生理或功能异常。分析了队列特征和医疗保健利用措施。使用与 GD 相关的主要诊断出院来估计最小负担;与 GD 相关的主要或次要代码的放电确定了最大负担。结果 585 万次加权排放,2。6-14% 包括与 GD 相关的 ICD-9-CM 代码。对于这些出院,与背景相比,新生儿的平均总费用高出 16,000-77,000 美元(P < 0.0001),儿科患者的平均总费用高出 12,000-17,000 美元(P < 0.0001),相应的总费用和住院时间显着增加。2012 年,疑似 GD 的总费用占儿科患者“国家账单”的 14 至 570 亿美元(11-46%)。结论与遗传病相关的诊断代码的儿科住院患者对资源和成本产生了显着且不成比例的影响在美国的医疗保健系统中。对应于显着更高的总费用和逗留时间。2012 年,疑似 GD 的总费用占儿科患者“国家账单”的 14 至 570 亿美元(11-46%)。结论与遗传病相关的诊断代码的儿科住院患者对资源和成本产生了显着且不成比例的影响在美国的医疗保健系统中。对应于显着更高的总费用和逗留时间。2012 年,疑似 GD 的总费用占儿科患者“国家账单”的 14 至 570 亿美元(11-46%)。结论与遗传病相关的诊断代码的儿科住院患者对资源和成本产生了显着且不成比例的影响在美国的医疗保健系统中。
更新日期:2019-01-26
down
wechat
bug