Background

Clear cell acanthoma (CCA) of the nipple/areola has been reported. The CCA-like histology more likely represents a feature of eczematous dermatitis of the nipple/areola.

Objective

We reviewed cases of CCA-like lesions of the nipple/areola and compared them with classic CCA to clarify their relationship.

Methods

The clinicopathological features of 12 cases of CCA-like lesions of the nipple/areola were compared with classic CCA. The literature on this condition was reviewed, and the results of various treatments were analyzed.

Results

CCA-like lesions of the nipple/areola were clinically different from those of classic CCA. Although they shared the glycogen-rich clear epidermal cells with neutrophilic exocytosis, dermal eosinophils appeared to be a distinctive feature. The anatomic site and association with atopic dermatitis suggested that CCA-like lesions of nipple/areola might represent a manifestation of atopic eczema involving nipple/areola. Topical steroids could be effective.

Limitations

This was a retrospective study with limited cases.

Conclusions

Although CCA-like lesions of the nipple/areola shared histopathological features with classic CCA, their clinical changes were consistent with dermatitis. We propose to name this condition CCA-like eczematous dermatitis of the nipple/areola.

中文翻译：

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乳头/乳晕的透明细胞棘皮瘤（CCA）样病变：支持非肿瘤性湿疹疾病的12例临床病理研究

背景

乳头/乳晕的透明细胞棘皮瘤（CCA）已有报道。类似于CCA的组织学更可能代表乳头/乳晕的湿疹性皮炎的特征。

客观的

我们审查了乳头/乳晕的CCA样病变病例，并将其与经典CCA进行了比较，以阐明它们之间的关系。

方法

将12例乳头/乳晕CCA样病变的临床病理特征与经典CCA进行了比较。文献综述了这种情况，并分析了各种治疗方法的结果。

结果

乳头/乳晕的CCA样病变在临床上不同于经典CCA。尽管他们与嗜中性白细胞增多症患者共享富含糖原的透明表皮细胞，但皮肤嗜酸性粒细胞似乎是一个独特的特征。解剖部位以及与特应性皮炎的关系表明，乳头/乳晕的CCA样病变可能代表涉及乳头/乳晕的特应性湿疹的表现。外用类固醇可能是有效的。

局限性

这是一项病例有限的回顾性研究。

结论

尽管乳头/乳晕的CCA样病变与经典CCA具有相同的组织病理学特征，但其临床变化与皮炎一致。我们建议将这种情况命名为乳头/乳晕的CCA样湿疹性皮炎。