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Benefits of Unconventional Methods in the Total Synthesis of Natural Products.
ACS Omega ( IF 3.7 ) Pub Date : 2018-12-14 , DOI: 10.1021/acsomega.8b02994 Tomas Hudlicky 1
ACS Omega ( IF 3.7 ) Pub Date : 2018-12-14 , DOI: 10.1021/acsomega.8b02994 Tomas Hudlicky 1
Affiliation
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This article provides a survey of four "unconventional" methods employed in the synthesis of natural products in the Hudlicky group. The utility of flash vacuum pyrolysis is highlighted by examples of many natural products attained via vinylcyclopropane-cyclopentene rearrangement and its heterocyclic variants. Preparative organic electrochemistry was used in oxidations and reductions with levels of selectivity unattainable by conventional methods. Yeast reduction of ketoesters was featured in the total synthesis of pyrrolizidine alkaloids. Finally, the use of toluene dioxygenase-mediated dihydroxylations in enantioselective synthesis of natural products concludes this presentation. Recently, synthesized targets in the period 2010-2019 are listed in the accompanying table. The results of research from the Hudlicky group are placed in appropriate context with the work of others, and a detailed guide to the current literature is provided.
中文翻译：
非常规方法在天然产物全合成中的优势。
本文概述了Hudlicky组中用于合成天然产物的四种“非常规”方法。闪蒸真空热解的实用性通过通过乙烯基环丙烷-环戊烯重排及其杂环变体获得的许多天然产物的实例得到了强调。制备有机电化学用于氧化和还原，其选择性水平是常规方法无法达到的。吡咯并立核生物碱的全合成具有降低酮酸酯的酵母的特征。最后，在天然产物的对映选择性合成中使用甲苯双加氧酶介导的二羟基化反应结束了本报告。最近，下表列出了2010-2019年期间的综合目标。
更新日期：2018-12-14
中文翻译：
非常规方法在天然产物全合成中的优势。
本文概述了Hudlicky组中用于合成天然产物的四种“非常规”方法。闪蒸真空热解的实用性通过通过乙烯基环丙烷-环戊烯重排及其杂环变体获得的许多天然产物的实例得到了强调。制备有机电化学用于氧化和还原，其选择性水平是常规方法无法达到的。吡咯并立核生物碱的全合成具有降低酮酸酯的酵母的特征。最后，在天然产物的对映选择性合成中使用甲苯双加氧酶介导的二羟基化反应结束了本报告。最近，下表列出了2010-2019年期间的综合目标。
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