A diet enriched with curcumin promotes resilience to chronic social defeat stress.,Neuropsychopharmacology

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A diet enriched with curcumin promotes resilience to chronic social defeat stress.
Neuropsychopharmacology ( IF 6.6 ) Pub Date : 2018-12-12 , DOI: 10.1038/s41386-018-0295-2
Antonio V Aubry _{1,

2} , Hameda Khandaker _{1,

3} , Rebecca Ravenelle _{1,

4} , Itamar S Grunfeld _{1,

3} , Valentina Bonnefil ₅ , Kenny L Chan ₂ , Flurin Cathomas ₂ , Jia Liu ₅ , Glenn E Schafe _{1,

3} , Nesha S Burghardt _{1,

3}

Affiliation

Chronic exposure to stress is a well-known risk factor for the development of mood and anxiety disorders. Promoting resilience to stress may prevent the development of these disorders, but resilience-enhancing compounds are not yet clinically available. One compound that has shown promise in the clinical setting is curcumin, a polyphenol compound found in the rhizome of the turmeric plant (Curcuma longa) with known anti-inflammatory and antidepressant properties. Here, we tested the efficacy of 1.5% dietary curcumin at promoting resilience to chronic social defeat stress (CSDS) in 129/SvEv mice, a strain that we show is highly susceptible to this type of stress. We found that administration of curcumin during CSDS produced a 4.5-fold increase in stress resilience, as measured by the social interaction test. Although the overall effects of curcumin were striking, we identified two distinct responses to curcumin. While 64% of defeated mice on curcumin were resilient (responders), the remaining 36% of mice were susceptible to the effects of stress (non-responders). Interestingly, responders released less corticosterone following acute restraint stress and had lower levels of peripheral IL-6 than nonresponders, implicating a role for the NF-κB pathway in treatment response. Importantly, curcumin also prevented anxiety-like behavior in both responders and non-responders in the elevated-plus maze and open field test. Collectively, our findings provide the first preclinical evidence that curcumin promotes resilience to CSDS and suggest that curcumin may prevent the emergence of a range of anxiety-like symptoms when given to individuals during exposure to chronic social stress.

中文翻译：

富含姜黄素的饮食可以增强对慢性社交失败压力的恢复能力。

众所周知，长期承受压力是导致情绪和焦虑症的危险因素。增强对压力的抵抗力可能会阻止这些疾病的发展，但增强抵抗力的化合物尚未在临床上可用。姜黄素是一种在临床环境中显示出前景的化合物，它是一种在姜黄植物 (Curcuma longa) 根茎中发现的多酚化合物，具有已知的抗炎和抗抑郁特性。在这里，我们测试了 1.5% 膳食姜黄素在促进 129/SvEv 小鼠对慢性社交挫败压力 (CSDS) 的恢复能力方面的功效，我们证明该品系对此类压力高度敏感。我们发现，根据社交互动测试的测量，在 CSDS 期间服用姜黄素可使压力恢复能力提高 4.5 倍。尽管姜黄素的总体效果是惊人的，但我们发现了对姜黄素的两种不同的反应。虽然姜黄素治疗失败的小鼠中有 64% 具有恢复能力（有反应者），但其余 36% 的小鼠容易受到压力的影响（无反应者）。有趣的是，与无反应者相比，有反应者在急性束缚应激后释放的皮质酮较少，并且外周 IL-6 水平较低，这表明 NF-κB 通路在治疗反应中发挥作用。重要的是，姜黄素还可以防止高架正迷宫和旷场测试中反应者和非反应者的焦虑样行为。总的来说，我们的研究结果提供了第一个临床前证据，表明姜黄素可以促进 CSDS 的恢复力，并表明在暴露于慢性社会压力期间，姜黄素可以预防一系列焦虑样症状的出现。

更新日期：2019-01-26

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