Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases.,Mucosal Immunology

当前位置： X-MOL 学术 › Mucosal Immunol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Batf2 differentially regulates tissue immunopathology in Type 1 and Type 2 diseases.
Mucosal Immunology ( IF 7.9 ) Pub Date : 2018-Dec-12 , DOI: 10.1038/s41385-018-0108-2
Reto Guler _{1,

2,

3} , Thabo Mpotje _{1,

2} , Mumin Ozturk _{1,

2} , Justin K Nono _{1,

2,

4} , Suraj P Parihar _{1,

2,

3,

5} , Julius Ebua Chia _{1,

2} , Nada Abdel Aziz _{1,

2,

6} , Lerato Hlaka _{1,

2} , Santosh Kumar _{1,

2} , Sugata Roy ₇ , Adam Penn-Nicholson ₈ , Willem A Hanekom ₈ , Daniel E Zak ₉ , Thomas J Scriba ₈ , Harukazu Suzuki ₇ , Frank Brombacher _{1,

2,

3}

Affiliation

International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, 7925, South Africa.
Department of Pathology, University of Cape Town, Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC) Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town, 7925, South Africa.
Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa), Institute of Infectious Diseases and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town, 7925, South Africa.
The Medical Research Centre, Institute of Medical Research and Medicinal Plant Studies (IMPM), Ministry of Scientific Research and Innovation, Yaoundé, Cameroon.
Division of Medical Microbiology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, 7925, South Africa.
Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt.
RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan.
South African Tuberculosis Vaccine Initiative, Division of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, 7925, South Africa.
The Center for Infectious Disease Research, Seattle, WA, 98109, USA.

Basic leucine zipper transcription factor 2 (Batf2) activation is detrimental in Type 1-controlled infectious diseases, demonstrated during infection with Mycobacterium tuberculosis (Mtb) and Listeria monocytogenes Lm. In Batf2-deficient mice (Batf2^-/-), infected with Mtb or Lm, mice survived and displayed reduced tissue pathology compared to infected control mice. Indeed, pulmonary inflammatory macrophage recruitment, pro-inflammatory cytokines and immune effectors were also decreased during tuberculosis. This explains that batf2 mRNA predictive early biomarker found in active TB patients is increased in peripheral blood. Similarly, Lm infection in human macrophages and mouse spleen and liver also increased Batf2 expression. In striking contrast, Type 2-controlled schistosomiasis exacerbates during infected Batf2^-/- mice with increased intestinal fibro-granulomatous inflammation, pro-fibrotic immune cells, and elevated cytokine production leading to wasting disease and early death. Together, these data strongly indicate that Batf2 differentially regulates Type 1 and Type 2 immunity in infectious diseases.

中文翻译：

Batf2 在 1 型和 2 型疾病中差异调节组织免疫病理学。

碱性亮氨酸拉链转录因子 2 (Batf2) 激活在 1 型控制的传染病中是有害的，这在结核分枝杆菌 (Mtb) 和单核细胞增生李斯特菌 Lm 感染期间得到证实。在 Batf2 缺陷小鼠中（Batf2 ^-/-)，与受感染的对照小鼠相比，感染 Mtb 或 Lm 的小鼠存活并显示组织病理学减少。事实上，肺部炎性巨噬细胞募集、促炎细胞因子和免疫效应因子在结核病期间也有所减少。这解释了在活动性结核病患者中发现的 batf2 mRNA 预测性早期生物标志物在外周血中增加。同样，人类巨噬细胞和小鼠脾脏和肝脏中的 Lm 感染也增加了 Batf2 的表达。形成鲜明对比的是，2 型控制的血吸虫病在 Batf2 感染期间恶化^-/-肠道纤维肉芽肿性炎症、促纤维化免疫细胞增加和细胞因子产生增加导致消耗性疾病和早期死亡的小鼠。总之，这些数据有力地表明 Batf2 对传染病中的 1 型和 2 型免疫有不同的调节作用。

更新日期：2019-01-26

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11