OBJECTIVE Victimized adolescents have an increased risk of self-injurious thoughts and behaviors. However, poor understanding of causal and non-causal mechanisms underlying this observed risk limits the development of interventions to prevent premature death in adolescents. This study tested whether pre-existing family-wide and individual vulnerabilities account for victimized adolescents' increased risk of self-injurious thoughts and behaviors. METHOD Participants were 2,232 British children followed from birth to 18 years of age as part of the Environmental Risk Longitudinal Twin Study. Adolescent victimization (maltreatment, neglect, sexual victimization, family violence, peer/sibling victimization, cyber victimization, and crime victimization) was assessed through interviews with participants and co-informant questionnaires at the 18-year assessment. Suicidal ideation, self-harm, and suicide attempt in adolescence were assessed through interviews with participants at 18 years. RESULTS Victimized adolescents had an increased risk of suicidal ideation (odds ratio [OR] 2.40, 95% CI 2.11-2.74), self-harm (OR 2.38, 95% CI 2.10-2.69), and suicide attempt (OR 3.14, 95% CI 2.54-3.88). Co-twin control and propensity score matching analyses showed that these associations were largely accounted for by pre-existing familial and individual vulnerabilities, respectively. Over and above their prior vulnerabilities, victimized adolescents still showed a modest increase in risk for suicidal ideation (OR 1.45, 95%CI 1.10-1.91) and self-harm (OR 1.50, 95% CI 1.18-1.91) but not for suicide attempt (OR 1.28, 95% CI 0.83-1.98). CONCLUSION Risk for self-injurious thoughts and behaviors in victimized adolescents is explained only in part by the experience of victimization. Pre-existing vulnerabilities account for a large proportion of the risk. Therefore, effective interventions to prevent premature death in victimized adolescents should not only target the experience of victimization but also address pre-existing vulnerabilities.

中文翻译：

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青少年受害与自我伤害的思想与行为：一项对遗传敏感的队列研究。

目标受害青少年的自残思想和行为的风险增加。但是，对于这种观察到的风险背后的因果和非因果机制的了解不足，限制了预防青少年过早死亡的干预措施的发展。这项研究测试了先前存在的家庭和个人的脆弱性是否能解释受害青少年自残性思想和行为的风险增加。方法作为环境风险纵向双胞胎研究的一部分，参与者为2,232名从出生到18岁的英国儿童。青少年受害（虐待，忽视，性受害，家庭暴力，同伴/兄弟姐妹受害，网络受害，和犯罪受害者）在18年的评估中通过与参与者的访谈和共同信息调查表进行评估。通过与18岁的参与者进行访谈，评估了青少年的自杀意念，自我伤害和自杀未遂。结果受害青少年自杀意念的风险增加（赔率[OR] 2.40，95％CI 2.11-2.74），自残（OR 2.38，95％CI 2.10-2.69）和自杀未遂的风险（OR 3.14，95％ CI 2.54-3.88）。双胞胎控制和倾向得分匹配分析表明，这些关联在很大程度上是由各自存在的家族和个体脆弱性造成的。受害青少年除了其先前的脆弱性外，其自杀意念（OR 1.45，95％CI 1.10-1.91）和自我伤害（OR 1.50，95％CI 1.18-1）的风险仍然适度增加。91），但不是自杀未遂（OR 1.28，95％CI 0.83-1.98）。结论受害青少年自我伤害的思想和行为的风险仅部分由受害经历来解释。预先存在的漏洞占了很大比例的风险。因此，防止受害青少年过早死亡的有效干预措施不仅应针对受害的经历，而且应解决先前存在的脆弱性。