The possible hydrolysis of various Novichok agents and products of their degradation by organophosphorus hydrolase (OPH) and its genetically His₆-modified form was investigated by computer modeling via docking of substrate to enzyme active center. Magnitude of potential values of catalytic characteristics of enzyme(s) with such substrates was estimated.

中文翻译：

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诺维可克试剂可疑酶解的理论评估

通过计算机建模，通过底物与酶活性中心的对接，研究了各种Novichok试剂可能的水解及其通过有机磷水解酶（OPH）降解的产物及其遗传上的His ₆修饰形式。估计了具有这种底物的酶催化特性的潜在值的大小。