Autoimmune disease (AID) is a condition in which the immune system breaks down and starts to attack the body. Some common AIDs include rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes mellitus and so forth. The changes in T-cell receptor (TCR) repertoire have been found in several autoimmune diseases, and may be responsible for the breakdown of peripheral immune tolerance. In this review, we discussed the processes of TCR revision in peripheral immune environment, the changes in TCR repertoire that occurred in various AIDs, and the specifically expanded T cell clones. We hope our discussion can provide insights for the future studies, helping with the discovery of disease biomarkers and expanding the strategies of immune-targeted therapy.

自身免疫性疾病（AID）是一种免疫系统崩溃并开始攻击人体的疾病。一些常见的AID包括类风湿关节炎，系统性红斑狼疮，1型糖尿病等。在几种自身免疫性疾病中发现了T细胞受体（TCR）组成的变化，这可能是导致外周免疫耐受性下降的原因。在这篇综述中，我们讨论了外周免疫环境中TCR修订的过程，各种AID中发生的TCR组成变化以及特异扩增的T细胞克隆。我们希望我们的讨论可以为将来的研究提供见识，帮助发现疾病生物标记并扩展免疫靶向治疗的策略。