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Mn‐Catalyzed Electrochemical Synthesis of Quinazolinones from Primary Alcohols/Benzyl Ethers and o‐Aminobenzamides
ChemElectroChem ( IF 4 ) Pub Date : 2019-01-10 , DOI: 10.1002/celc.201801502
Dian‐Zhao Lin 1 , Yin‐Long Lai 1 , Jing‐Mei Huang 1
Affiliation  

An efficient approach for the synthesis of quinazolinones from o‐aminobenzamides and alcohols by the combination of electrochemistry and redox‐metal catalysis has been developed. Taking manganese(II) sulfate as a redox catalyst, this transformation proceeded smoothly under ambient conditions in an undivided cell to afford quinazolinones in moderate to excellent yields with a wide substrate scope. Benzyl ethers were also suitable participants in the cascade cyclization sequence.

中文翻译:

由伯醇/苄醚和邻氨基苯甲酰胺进行锰催化电化学合成喹唑啉酮

已开发出一种通过电化学和氧化还原金属催化相结合从氨基苯甲酰胺和醇类合成喹唑啉酮的有效方法。以硫酸锰(II)作为氧化还原催化剂,该转化在环境条件下在一个未分格的电池中顺利进行,从而以中等至极好的收率得到喹唑啉酮,具有广泛的底物范围。苄基醚也是级联环化序列的合适参与者。
更新日期:2019-01-10
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