Microneedle‐Array Patch Fabricated with Enzyme‐Free Polymeric Components Capable of On‐Demand Insulin Delivery,Advanced Functional Materials

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Microneedle‐Array Patch Fabricated with Enzyme‐Free Polymeric Components Capable of On‐Demand Insulin Delivery
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-12-09 , DOI: 10.1002/adfm.201807369
Siyuan Chen _{1,

2} , Hiroko Matsumoto ₂ , Yuki Moro‐oka ₂ , Miyako Tanaka ₃ , Yuji Miyahara ₂ , Takayoshi Suganami ₃ , Akira Matsumoto _{1,

2}

Affiliation

Achieving persistent glycemic control in a painless and convenient way is the ultimate goal of diabetes management. Herein, an “enzyme‐free” polymeric microneedle (MN)‐array patch composed of a boronate‐containing hydrogel semi‐interpenetrated by biocompatible silk fibroin is developed. Consistent with the previous reports, the presence of the boronate‐hydrogel allows for glucose‐responsive diffusion‐control of insulin, while the crystalline fibroin component serves as a matrix‐stiffener to validate skin penetration. Remarkably, this “enzyme‐free” smart artificial on‐skin pancreas prototype remains stable for at least 2 months in an aqueous environment. Furthermore, it establishes sustained as well as acute glucose‐responsive insulin delivery, and is to the authors' knowledge, the first successful material design addressing such two technical challenges at once on an MN format. This long‐acting, on‐demand insulin delivery technology may offer a candidate for a next‐generation diabetes therapy that is remarkably stable, safe, economically efficient, and capable of providing both acute‐ and continuous glycemic control in a manner minimally dependent on patient compliance.

中文翻译：

微针阵列贴片由无酶聚合成分制成，能够按需提供胰岛素

以无痛且方便的方式实现持续的血糖控制是糖尿病管理的最终目标。本文中，开发了一种“无酶”聚合物微针（MN）阵列贴片，该贴片由含硼酸盐的水凝胶半互穿生物相容性丝素蛋白组成。与以前的报告一致，硼酸盐水凝胶的存在可以控制胰岛素的葡萄糖响应扩散，而晶体丝蛋白成分则可以作为基质增强剂来验证皮肤渗透能力。值得注意的是，这种“无酶”智能人造皮肤胰腺原型在水性环境中可稳定至少2个月。此外，据作者所知，它可以建立持续的以及急性的葡萄糖反应性胰岛素输送。首次成功的材料设计以MN格式一次解决了这两个技术难题。这项长效，按需提供胰岛素的技术可能为下一代糖尿病治疗提供候选方案，该治疗方案非常稳定，安全，经济有效，并且能够以对患者的依赖性最小的方式提供急性和持续血糖控制遵守。

更新日期：2018-12-09

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