Fuel fine particulate matter (FPM) is an important component of ambient pollution, has wide biological activity, and can cause a variety of diseases. Epidemiological studies have reported that FPM can decrease human fertility rates, retard embryonic growth, cause adverse effects on pregnancy outcomes, and result in male reproductive damage. However, the effects of FPM on female ovary function and associated mechanisms are still unclear. In this research, different concentrations of gasoline and diesel FPM were chosen to treat female mice in vivo. Fuel FPM can significantly inhibit ovarian function and follicle maturation. The hypothalamus–pituitary–ovary axis was inhibited significantly, with an increase in follicle-stimulating hormone and luteinizing hormone levels and a decrease in estradiol levels, as well as ovary weight loss, which was similar to the symptoms of premature ovarian failure in humans. Fuel FPM can induce the accumulation of copper and lead in the ovary and decrease the levels of zinc, magnesium, and manganese. Simultaneously, the steroid biosynthesis signaling pathway was downregulated, which can contribute to ovarian dysfunction. This study provided a new perspective for understanding the ovarian toxicity of fuel FPM and associated mechanisms, which will aid in the development of new methods to treat ovarian dysfunction induced by FPM.

中文翻译：

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燃料细颗粒物通过金属元素失衡和类固醇生物合成信号通路抑制诱导卵巢功能障碍

燃料细颗粒物（FPM）是环境污染的重要组成部分，具有广泛的生物活性，并可能导致多种疾病。流行病学研究表明，FPM可以降低人类的生育率，延缓胚胎的生长，对妊娠结局产生不利影响，并导致男性生殖损伤。但是，FPM对女性卵巢功能及其相关机制的影响尚不清楚。在这项研究中，选择了不同浓度的汽油和柴油FPM来体内治疗雌性小鼠。燃料FPM可以显着抑制卵巢功能和卵泡成熟。下丘脑-垂体-卵巢轴受到明显抑制，促卵泡激素和促黄体生成素的水平增加，雌二醇水平降低，卵巢体重减轻，这类似于人类卵巢早衰的症状。燃料FPM可以引起铜和铅在子房中的积累，并降低锌，镁和锰的含量。同时，类固醇的生物合成信号通路被下调，这可能导致卵巢功能障碍。这项研究为理解燃料FPM的卵巢毒性及其相关机理提供了新的视角，这将有助于开发新的方法来治疗FPM引起的卵巢功能障碍。