Two undescribed prenylbenzaldehyde derivatives, cristaldehydes A and B, and an undescribed quinone derivative, cristaquinone A, along with seven known compounds were isolated from the fungus Eurotium cristatum. The structures of undescribed compounds were determined by spectroscopic analysis including NMR, HR-ESIMS, and single-crystal X-ray diffraction. This is the first report of identification of a dibenzannulated 6,6-spiroketal derivative, cristaldehyde B, in a natural product. Cytotoxic and anti-inflammatory activities of all compounds were evaluated. Cristaldehyde A and cristaquinone A along with five known compounds showed significant anti-inflammatory activities with IC50 values in the range from 0.37 to 14.50 μM.

中文翻译：

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从嵴中分离的抗炎异戊二烯苯甲醛衍生物

从真菌 Eurotium cristatum 中分离出两种未描述的异戊二烯基苯甲醛衍生物、新戊醛 A 和 B，以及一种未描述的醌衍生物新苯醌 A 以及七种已知化合物。未描述化合物的结构通过光谱分析确定，包括 NMR、HR-ESIMS 和单晶 X 射线衍射。这是在天然产物中鉴定出二苯环化 6,6-螺缩酮衍生物 cristaldehyde B 的第一份报告。评估了所有化合物的细胞毒性和抗炎活性。Cristaldehyde A 和 cristaquinone A 以及五种已知化合物显示出显着的抗炎活性，IC50 值在 0.37 到 14.50 μM 的范围内。