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Generic Assay of Sulfur-Containing Compounds Based on Kinetics Inhibition of Gold Nanoparticle Photochemical Growth.
ACS Omega ( IF 3.7 ) Pub Date : 2018-12-07 , DOI: 10.1021/acsomega.8b02804
Anastasia Kostara 1 , George Z Tsogas 1 , Athanasios G Vlessidis 1 , Dimosthenis L Giokas 1
Affiliation  

This work describes a new, equipment-free, generic method for the determination of sulfur-containing compounds that is based on their ability to slow down the photoreduction kinetics of gold ions to gold nanoparticles. The method involves tracking the time required for a red coloration to appear in the tested sample, indicative of the formation of gold nanoparticles, and compare the measured time relative to a control sample in the absence of the target analyte. The method is applicable with minimal and simple steps requiring only two solutions (i.e., a buffer and a gold solution), a source of light (UV or visible), and a timer. The method responds to a large variety of sulfur-containing compounds including thiols, thioesters, disulfides, thiophosphates, metal-sulfur bonds, and inorganic sulfur and was therefore applied to the determination of a variety of compounds such as dithiocarbamate and organophosphorous pesticides, biothiols, pharmaceutically active compounds, and sulfides in different samples such as natural waters and wastewater, biological fluids, and prescription drugs. The analytical figures of merit of the method include satisfactory sensitivity (quantitation limits at the low μM levels), good recoveries (from 93 to 109%), and satisfactory reproducibility (from 4.8 to 9.8%). The method is easily adoptable to both laboratory settings and nonlaboratory conditions for quantitative and semiquantitative analysis, respectively, is user-friendly even for the minimally trained user, and can be performed with limited resources at low cost.

中文翻译:

基于动力学抑制金纳米粒子光化学生长的含硫化合物的通用测定。

这项工作描述了一种新的无需设备的通用方法来测定含硫化合物,该方法基于其减慢金离子向金纳米颗粒的光还原动力学的能力。该方法包括跟踪红色在测试样品中出现所需的时间,该时间指示金纳米颗粒的形成,并在不存在目标分析物的情况下将测量的时间与对照样品进行比较。该方法适用于最少且简单的步骤,仅需要两种溶液(即缓冲液和金溶液),光源(紫外线或可见光)和计时器。该方法可应对多种含硫化合物,包括硫醇,硫酯,二硫化物,硫代磷酸盐,金属-硫键,无机硫,因此可用于测定各种样品(如天然水和废水,生物液和处方药)中的各种化合物,例如二硫代氨基甲酸酯和有机磷农药,生物硫醇,药物活性化合物和硫化物。该方法的分析性能指标包括令人满意的灵敏度(低μM水平的定量限),良好的回收率(从93%到109%)和令人满意的重现性(从4.8%到9.8%)。该方法可容易地分别应用于实验室设置和非实验室条件下以进行定量和半定量分析,即使对于受过最少培训的用户,也易于使用,并且可以用有限的资源以低成本进行。
更新日期:2018-12-07
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