Chiral iminophosphorane catalyzed asymmetric sulfenylation of 4-substituted pyrazolones†,Chemical Communications

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Chiral iminophosphorane catalyzed asymmetric sulfenylation of 4-substituted pyrazolones†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-12-06 00:00:00 , DOI: 10.1039/c8cc09049a
Jianwei Han _{1,

2,

3,

4,

5} , Yanxia Zhang _{1,

2,

3,

4,

5} , Xin-Yan Wu _{1,

2,

3,

4,

5} , Henry N. C. Wong _{6,

7,

8,

9,

10}

Affiliation

An excellent level of enantioselectivity in asymmetric sulfenylation of 4-substituted pyrazolones was achieved with chiral iminophosphorane as the organocatalyst under continuum solvation conditions (up to 99% ee). Importantly, this catalytic process features high efficiency with excellent enantioselectivities, easy separation of products, low catalytic loadings and scale-up to grams without loss of enantioselectivity.

中文翻译：

手性亚氨基膦烷催化4-取代的吡唑啉酮的不对称亚磺酰基†

在连续溶剂化条件下（手感高达99％ee），使用手性亚氨基膦烷作为有机催化剂，可以实现4-取代吡唑啉酮不对称亚磺酰化反应中优异的对映选择性。重要的是，该催化过程的特点是效率高，对映选择性优异，产物易于分离，催化负载低，按比例放大至克，而不会损失对映选择性。

更新日期：2018-12-06

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