In human cells, the p62 protein acts as an adaptor in various signaling pathways as well as a receptor for selective autophagy. In this issue of Science Signaling, Sanchez-Garrido et al. show that proteolytic cleavage of p62 by caspase-8 determines whether p62 functions as an mTORC1 signaling adaptor or autophagy receptor.

中文翻译：

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mTORC1信号转导和自噬中的分工

在人类细胞中，p62蛋白在各种信号传导途径中充当衔接子，并在选择性自噬中起受体作用。在本期《科学信号》中，Sanchez-Garrido等人。证明了caspase-8对p62的蛋白水解切割决定了p62是否充当mTORC1信号转导接头或自噬受体。