Rationalization of stereoselectivity in enzyme reactions,Wiley Interdisciplinary Reviews: Computational Molecular Science

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Rationalization of stereoselectivity in enzyme reactions
Wiley Interdisciplinary Reviews: Computational Molecular Science ( IF 16.8 ) Pub Date : 2018-12-05 , DOI: 10.1002/wcms.1403
H. C. Stephen Chan _{1,

2} , Lu Pan ₃ , Yi Li ₄ , Shuguang Yuan _{1,

5}

Affiliation

Enzymes are responsible for more than 5,000 different types of biochemical reactions. Enzymes speed up various chemical reactions in cell that would otherwise take millions of years to occur in milliseconds. The ability to discriminate between optical isomers is vital for living systems. The selective formation of only one product stereoisomer from achiral substrates is one of the most sophisticated tasks for enzymes. Because of the importance of stereoselectivity in biology, the structural and mechanistic basis underlying these phenomena has become the subject of intensive research. Enzymatic reactions provide the basis of cellular biochemistry and typically display high stereoselectivity. With the advances of enzyme engineering, in vitro evolution and, especially, computational rational design, scientists start to provide various methods and tools to manipulate the stereoselective properties of enzymes. To gain an insightful view of stereoselectivity in enzyme reactions, we present an extensive discussion on the latest progresses in this area.

中文翻译：

酶反应中立体选择性的合理化

酶负责5,000多种不同类型的生化反应。酶会加速细胞中的各种化学反应，否则这些化学反应将需要数百万年才能在毫秒内发生。区分光学异构体的能力对于生命系统至关重要。从非手性底物中仅形成一种产物立体异构体是酶最复杂的任务之一。由于立体选择性在生物学中的重要性，这些现象背后的结构和机理基础已成为深入研究的主题。酶促反应提供了细胞生物化学的基础，通常显示出高的立体选择性。随着酶工程，体外进化尤其是计算合理设计的进步，科学家开始提供各种方法和工具来操纵酶的立体选择性。为了深入了解酶反应中的立体选择性，我们对这一领域的最新进展进行了广泛的讨论。

更新日期：2018-12-05

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