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Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-12-04 00:00:00 , DOI: 10.1021/acs.chemrev.8b00136 Christine F Markwalter 1 , Andrew G Kantor 1 , Carson P Moore 1 , Kelly A Richardson 1 , David W Wright 1
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-12-04 00:00:00 , DOI: 10.1021/acs.chemrev.8b00136 Christine F Markwalter 1 , Andrew G Kantor 1 , Carson P Moore 1 , Kelly A Richardson 1 , David W Wright 1
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Infectious diseases claim millions of lives each year. Robust and accurate diagnostics are essential tools for identifying those who are at risk and in need of treatment in low-resource settings. Inorganic complexes and metal-based nanomaterials continue to drive the development of diagnostic platforms and strategies that enable infectious disease detection in low-resource settings. In this review, we highlight works from the past 20 years in which inorganic chemistry and nanotechnology were implemented in each of the core components that make up a diagnostic test. First, we present how inorganic biomarkers and their properties are leveraged for infectious disease detection. In the following section, we detail metal-based technologies that have been employed for sample preparation and biomarker isolation from sample matrices. We then describe how inorganic- and nanomaterial-based probes have been utilized in point-of-care diagnostics for signal generation. The following section discusses instrumentation for signal readout in resource-limited settings. Next, we highlight the detection of nucleic acids at the point of care as an emerging application of inorganic chemistry. Lastly, we consider the challenges that remain for translation of the aforementioned diagnostic platforms to low-resource settings.
中文翻译：
用于传染病诊断的无机复合物和金属基纳米材料
传染病每年夺去数百万人的生命。稳健而准确的诊断是识别那些在资源匮乏地区处于危险之中并需要治疗的人的重要工具。无机复合物和金属基纳米材料继续推动诊断平台和策略的发展，从而在资源匮乏的环境中实现传染病检测。在这篇综述中，我们重点介绍了过去 20 年的工作，其中无机化学和纳米技术应用于构成诊断测试的每个核心组件。首先，我们介绍如何利用无机生物标志物及其特性进行传染病检测。在下一节中，我们将详细介绍用于样品制备和从样品基质中分离生物标志物的金属技术。然后，我们描述了如何利用基于无机和纳米材料的探针来产生信号的即时诊断。以下部分讨论资源有限设置中信号读出的仪器。接下来，我们重点介绍护理点核酸检测作为无机化学的新兴应用。最后，我们考虑将上述诊断平台转移到资源匮乏的环境中仍然面临的挑战。
更新日期：2018-12-04
中文翻译：
用于传染病诊断的无机复合物和金属基纳米材料
传染病每年夺去数百万人的生命。稳健而准确的诊断是识别那些在资源匮乏地区处于危险之中并需要治疗的人的重要工具。无机复合物和金属基纳米材料继续推动诊断平台和策略的发展，从而在资源匮乏的环境中实现传染病检测。在这篇综述中，我们重点介绍了过去 20 年的工作，其中无机化学和纳米技术应用于构成诊断测试的每个核心组件。首先，我们介绍如何利用无机生物标志物及其特性进行传染病检测。在下一节中，我们将详细介绍用于样品制备和从样品基质中分离生物标志物的金属技术。然后，我们描述了如何利用基于无机和纳米材料的探针来产生信号的即时诊断。以下部分讨论资源有限设置中信号读出的仪器。接下来，我们重点介绍护理点核酸检测作为无机化学的新兴应用。最后，我们考虑将上述诊断平台转移到资源匮乏的环境中仍然面临的挑战。
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