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Early impact of pulmonary stereotactic fractionated body radiotherapy (SBRT) on Quality of Life (QoL): Benefit for patients with low initial scores (STRIPE trial)
Journal of Thoracic Oncology ( IF 21.0 ) Pub Date : 2019-03-01 , DOI: 10.1016/j.jtho.2018.10.170
Sonja Adebahr , Marlene Hechtner , Nele Schräder , Tanja Schimek-Jasch , Klaus Kaier , Viola Duncker-Rohr , Eleni Gkika , Felix Momm , Jan Gaertner , Gerhild Becker , Anca-Ligia Grosu , Ursula Nestle

Introduction: Quality of life (QoL) of comorbid patients with pulmonary malignancies is a key issue in considering fractionated stereotactic body radiotherapy (SBRT) indication. This study investigates the early impact of SBRT on QoL. Methods: One hundred patients with pulmonary lesions were treated with SBRT from February 2011 to December 2014 within the prospective, monocenter, phase II STRIPE trial. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core module (EORTC QLQ‐C30) and the QLQ‐LC13 lung cancer‐specific questionnaire were used to evaluate QoL before, 2 and 7 weeks after SBRT, then every 3 months for 2 years. We report on the analysis of early changes from baseline to 7‐week follow‐up exam. Impact of patient‐ and treatment‐related factors on the change in QoL was analyzed. Results: QoL was assessed in 97 patients; compliance was 92% and 85% at baseline and 7 weeks after SBRT, respectively. No clinically relevant changes greater than or equal to 10 in the QoL/global health status (GHS), function scores and inquired symptoms were observed. Patients with baseline QoL below the median showed clinically relevant improvement in QoL/GHS (&Dgr;16.7 ± 25.3, p = 0.003), emotional function (&Dgr;14.4 ± 25.4, p = 0.013), and fatigue (&Dgr; ‐10.1 ± 26.5, p = 0.089) in contrast to patients with high initial scores. No changes were observed in the dichotomized subgroups of initial Karnofsky index, Charlson Comorbidity Index, age, diagnosis, and tumor localization. Conclusions: In short‐term follow‐up, QoL is well maintained after pulmonary SBRT. Especially patients with low initial QoL/GHS scores show benefit from SBRT with respect to QoL.

中文翻译:

肺立体定向分割放疗 (SBRT) 对生活质量 (QoL) 的早期影响:对初始评分低的患者有益(STRIPE 试验)

简介:肺部恶性肿瘤合并症患者的生活质量 (QoL) 是考虑分割立体定向放疗 (SBRT) 适应症的关键问题。本研究调查了 SBRT 对 QoL 的早期影响。方法:2011 年 2 月至 2014 年 12 月,在前瞻性、单中心、II 期 STRIPE 试验中,100 名肺部病变患者接受了 SBRT 治疗。欧洲癌症研究和治疗组织生活质量问卷核心模块 (EORTC QLQ-C30) 和 QLQ-LC13 肺癌特异性问卷用于评估 SBRT 前、2 周和 7 周后的 QoL,然后每 3 个月评估一次2年。我们报告了对从基线到 7 周随访检查的早期变化的分析。分析了患者和治疗相关因素对 QoL 变化的影响。结果:在 97 名患者中评估了 QoL;基线和 SBRT 后 7 周的依从性分别为 92% 和 85%。没有观察到 QoL/全球健康状况 (GHS)、功能评分和询问症状出现大于或等于 10 的临床相关变化。基线 QoL 低于中位数的患者在 QoL/GHS (&Dgr;16.7 ± 25.3, p = 0.003)、情绪功能 (&Dgr;14.4 ± 25.4, p = 0.013) 和疲劳 (&Dgr; ‐10.1 ± 26.5) 方面表现出临床相关的改善。 , p = 0.089) 与初始评分高的患者相反。在初始 Karnofsky 指数、Charlson 合并症指数、年龄、诊断和肿瘤定位的二分亚组中没有观察到变化。结论:在短期随访中,肺 SBRT 后 QoL 保持良好。
更新日期:2019-03-01
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