BACKGROUND This study examines the relationship between self-reported instances of major discrimination and inflammation among older adults, and explores whether this relationship varies in accordance with race/ethnicity. We hypothesized that self-reported instances of major discrimination would be associated with higher levels of high-risk inflammation and that this relationship would be stronger for racial/ethnic minorities than whites. METHODS Data from the 2006/2008 Health and Retirement Study, an ongoing biennial nationally representative sample of older adults in the United States, were used to collect measures of self-reported instances of major discrimination and high-risk C-reactive protein (CRP), which was assayed from blood samples. Modified Poisson regression with robust standard errors was applied to estimate the prevalence ratios of self-reported instances of major discrimination, as it relates to high-risk CRP (CRP ≥ 22 kg/m2), and test whether this relationship varies by race/ethnicity. RESULTS Respondents who experienced any instances of major discrimination had a higher likelihood of high-risk CRP (prevalence ratio [PR]: 1.14, 95% confidence interval [CI] = 1.07-1.22) than those who did not report experiencing any instances of major discrimination. This association was independent of differences in newly diagnosed health conditions and socioeconomic status. The relationship between any self-reported instance of major discrimination and high-risk CRP was weaker for blacks than whites (PR: 0.81, 95% CI = 0.69-0.95). CONCLUSIONS Our study confirms that self-reported instances of major lifetime discrimination is a psychosocial factor that is adversely associated with high-risk CRP among older adults; this association is especially pronounced among older whites. Future studies among this population are required to examine whether the relationship between self-reported instances of major discrimination and high-risk CRP changes over time.

中文翻译：

---

自我报告的老年人主要歧视，种族/民族和炎症实例：来自健康和退休研究的证据。

背景技术这项研究检查了老年人自我报告的主要歧视与炎症之间的关系，并探讨了这种关系是否根据种族/民族而变化。我们假设自我报告的重大歧视事件与较高的高危炎症水平相关，并且种族/族裔少数群体的这种关系将比白人更强。方法使用2006/2008年健康与退休研究的数据（美国正在进行的两年一度的具有代表性的美国老年人样本）收集了自我报告的主要歧视和高风险C反应蛋白（CRP）实例的量度，这是从血液样本中测定的。应用修正的Poisson回归和强大的标准误差来估计自我报告的主要歧视案例的患病率，因为它与高风险CRP（CRP≥22 kg / m2）有关，并检验这种关系是否因种族/民族而异。结果经历过任何重大歧视事件的受访者比未报告经历过任何重大事件的受访者发生高风险CRP的可能性更高（患病率[PR]：1.14，95％置信区间[CI] = 1.07-1.22）。歧视。这种关联独立于新诊断的健康状况和社会经济状况的差异。自我报告的任何重大歧视事件与高风险CRP之间的关系，黑人比白人弱（PR：0.81，95％CI = 0.69-0.95）。结论我们的研究证实，自我报告的重大一生歧视实例是一种社会心理因素，与老年人的高危CRP有害相关。这种联系在年长的白人中尤为明显。需要对该人群进行进一步的研究，以检查自我报告的主要歧视事件与高风险CRP之间的关系是否随时间变化。