Low molecular weight nucleoside gelators hold great promise in drug delivery and particularly for the delivery of biologics because of their excellent biocompatibility. However, the influence of these gelators on protein aggregation inhibition has not yet been studied. Protein aggregation is the most significant cause of protein instability and can severely impact the biological activity of the protein, impairing the quality and safety of the formulation. Herein, we report the ability of a nucleoside-based gelator, N4-octanoyl-2′-deoxycytidine, to inhibit protein aggregation. Using turbidimetric, spectroscopic, and microscopic methods, we demonstrate that protein aggregation inhibition is dependent on gelator concentration. Moreover, we have found that the protein is still functionally active in the hydrogel.

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低分子量核苷胶凝剂：抑制蛋白聚集的平台

低分子量核苷胶凝剂具有出色的生物相容性，因此在药物输送中尤其是在生物制剂的输送中具有广阔的前景。但是，尚未研究这些胶凝剂对蛋白质聚集抑制的影响。蛋白质聚集是蛋白质不稳定的最重要原因，并且可能严重影响蛋白质的生物学活性，从而损害制剂的质量和安全性。在这里，我们报告了基于核苷的胶凝剂N 4-辛酰基-2'-脱氧胞苷抑制蛋白质聚集的能力。使用比浊法，分光镜法和显微镜法，我们证明了蛋白质聚集抑制作用取决于胶凝剂的浓度。此外，我们发现蛋白质在水凝胶中仍具有功能活性。