Fe3O4–ZIF-8 assemblies as pH and glutathione responsive T2–T1 switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo†,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Fe3O4–ZIF-8 assemblies as pH and glutathione responsive T2–T1 switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-11-29 00:00:00 , DOI: 10.1039/c8cc08943d
Jiaomin Lin _{1,

2,

3,

4,

5} , Pengyan Xin _{1,

2,

3,

4,

5} , Lu An _{1,

2,

3,

4,

5} , Yanjun Xu _{6,

7,

8,

9,

10} , Cheng Tao _{1,

2,

3,

4,

5} , Qiwei Tian _{1,

2,

3,

4,

5} , Zhiguo Zhou _{1,

2,

3,

4,

5} , Bing Hu _{6,

7,

8,

9,

10} , Shiping Yang _{1,

2,

3,

4,

5}

Affiliation

A small Fe₃O₄ nanoparticles-based T₁ contrast agent was assembled into a pH- and glutathione-responsive T₂–T₁ switching contrast agent, Fe₃O₄–ZIF-8. In vivo T₁-weighted images of mice showed that Fe₃O₄–ZIF-8 displayed darkening contrast enhancement for liver sites, while darkening to brightening contrast enhancement at tumor sites, giving large inverse contrast for distinguishing the normal and tumor tissues.

中文翻译：

Fe ₃ O ₄ –ZIF-8组装成pH和谷胱甘肽响应性T ₂ – T ₁转换磁共振成像造影剂，用于体内敏感肿瘤成像†

将小的基于Fe ₃ O ₄纳米颗粒的T ₁造影剂组装成对pH和谷胱甘肽有响应的T ₂ – T ₁转换造影剂Fe ₃ O ₄ –ZIF-8。小鼠体内T ₁加权图像显示，Fe ₃ O ₄ –ZIF-8对肝脏部位显示出增强的对比度增强，而在肿瘤部位处表现出从暗到对比度增强的对比度，从而提供了大的反差以区分正常组织和肿瘤组织。

更新日期：2018-11-29

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11