Effects of Dietary Selenium Supplementation on Intestinal Barrier and Immune Responses Associated with Its Modulation of Gut Microbiota,Environmental Science & Technology Letters

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Effects of Dietary Selenium Supplementation on Intestinal Barrier and Immune Responses Associated with Its Modulation of Gut Microbiota
Environmental Science & Technology Letters ( IF 8.9 ) Pub Date : 2018-11-28 , DOI: 10.1021/acs.estlett.8b00563
Qixiao Zhai _{1,

2,

3,

4} , Shi Cen _{1,

2} , Peng Li _{1,

2} , Fengwei Tian _{1,

2} , Jianxin Zhao _{1,

2} , Hao Zhang _{1,

2,

5} , Wei Chen _{1,

2,

5,

6}

Affiliation

Variations in selenium (Se) intake have been reported to affect the barrier function and immune responses in the gut. Previous studies mainly focused on the role of Se itself or its metabolites, while the influences of the Se-intake-related microbiota on gut health were not thoroughly studied. This study compared the effects of different dietary Se supplementation (Se-deficient, Se-adequate, and Se-supranutritional) on the gut microbiota of mice. Fecal microbiota transplantation (FMT) was further conducted to bypass the effect of Se itself and provided direct evidence that the effects of dietary Se supplementation on the intestinal barrier and immune responses are associated with its modulation of the gut microbiota. Deficient Se supplementation can result in a phenotype of gut microbiota that is more susceptible to dextran sulfate sodium (DSS)-induced colitis and Salmonella typhimurium infection. Sufficient or supranutritional Se intake can optimize the gut microbiota for protection against these intestinal dysfunctions.

中文翻译：

膳食硒对肠道菌群调控的肠道屏障和免疫反应的影响

据报道硒摄入量的变化会影响肠道的屏障功能和免疫反应。以前的研究主要集中在硒本身或其代谢产物的作用上，而对硒摄入相关菌群对肠道健康的影响尚未进行深入研究。这项研究比较了不同饮食中补充硒（缺乏硒，充足硒和补充硒）对小鼠肠道菌群的影响。进一步进行了粪便微生物菌群移植（FMT），以绕过Se本身的作用，并提供直接证据表明，饮食中补充Se对肠道屏障和免疫反应的影响与其对肠道菌群的调节有关。鼠伤寒沙门氏菌感染。摄入足够或超量的硒可以优化肠道菌群，以保护肠道免受这些肠道功能障碍的侵害。

更新日期：2018-11-28

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