Glutamate signaling regulates neuronal activity and synaptic plasticity, which underlies learning and memory. In this issue of Science Signaling, Foster et al. found that metabotropic glutamate receptors mediate long-term potentiation in hippocampal neurons by mobilizing acidic endolysosomal Ca²⁺ stores through the intracellular messenger NAADP.

中文翻译：

---

通过酸性 Ca2+ 储存思考

谷氨酸信号调节神经元活动和突触可塑性，这是学习和记忆的基础。在本期《科学信号》中，福斯特等人。发现代谢型谷氨酸受体通过细胞内信使NAADP调动酸性内溶酶体Ca ²⁺储存来介导海马神经元的长期增强。