Smads are critical intracellular signal transducers for transforming growth factor-β (TGF-β) in mammalian cells. In this study, we have identified WD repeat-containing protein 74 (WDR74) as a novel transcriptional coactivator for Smads in the canonical TGF-β signaling pathway. Through direct interactions with Smad proteins, WDR74 enhances TGF-β-mediated phosphorylation and nuclear accumulation of Smad2 and Smad3. Consequently, WDR74 enables stronger transcriptional responses and more robust TGF-β-induced physiological responses. Our findings have elucidated a critical role of WDR74 in regulating TGF-β signaling.

中文翻译：

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WDR74在TGF-β信号传导中充当新型共激活因子

Smads是在哺乳动物细胞中转化生长因子-β（TGF-β）的关键细胞内信号转导子。在这项研究中，我们已经确定了包含WD重复序列的蛋白74（WDR74）是经典TGF-β信号通路中Smads的新型转录共激活因子。通过与Smad蛋白的直接相互作用，WDR74增强了TGF-β介导的Smad2和Smad3的磷酸化和核积累。因此，WDR74能够实现更强的转录反应和更强大的TGF-β诱导的生理反应。我们的发现阐明了WDR74在调节TGF-β信号传导中的关键作用。