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Genetic Control of Early Cell Lineages in the Mammalian Embryo
Annual Review of Genetics ( IF 8.7 ) Pub Date : 2018-11-26 00:00:00 , DOI: 10.1146/annurev-genet-120116-024544
Janet Rossant 1, 2
Affiliation  

Establishing the different lineages of the early mammalian embryo takes place over several days and several rounds of cell divisions from the fertilized egg. The resulting blastocyst contains the pluripotent cells of the epiblast, from which embryonic stem cells can be derived, as well as the extraembryonic lineages required for a mammalian embryo to survive in the uterine environment. The dynamics of the cellular and genetic interactions controlling the initiation and maintenance of these lineages in the mouse embryo are increasingly well understood through application of the tools of single-cell genomics, gene editing, and in vivo imaging. Exploring the similarities and differences between mouse and human development will be essential for translation of these findings into new insights into human biology, derivation of stem cells, and improvements in fertility treatments.

中文翻译:


哺乳动物胚胎早期细胞谱系的遗传控制。

建立早期哺乳动物胚胎的不同谱系需要花费几天的时间,并需要从受精卵中进行几轮细胞分裂。所产生的胚泡包含可以从其衍生胚胎干细胞的表皮细胞的多能细胞,以及哺乳动物胚胎在子宫环境中生存所需的胚外谱系。通过应用单细胞基因组学,基因编辑和体内成像工具,越来越多地了解控制小鼠胚胎中这些谱系的起始和维持的细胞和遗传相互作用的动力学。探索小鼠与人类发育之间的异同对于将这些发现转化为对人类生物学的新见解,干细胞的衍生,

更新日期:2018-11-26
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