当前位置: X-MOL 学术Annu. Rev. Genet. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The Multiple Levels of Mitonuclear Coregulation
Annual Review of Genetics ( IF 8.7 ) Pub Date : 2018-11-26 00:00:00 , DOI: 10.1146/annurev-genet-120417-031709
R. Stefan Isaac 1 , Erik McShane 1 , L. Stirling Churchman 1
Affiliation  

Together, the nuclear and mitochondrial genomes encode the oxidative phosphorylation (OXPHOS) complexes that reside in the mitochondrial inner membrane and enable aerobic life. Mitochondria maintain their own genome that is expressed and regulated by factors distinct from their nuclear counterparts. For optimal function, the cell must ensure proper stoichiometric production of OXPHOS subunits by coordinating two physically separated and evolutionarily distinct gene expression systems. Here, we review our current understanding of mitonuclear coregulation primarily at the levels of transcription and translation. Additionally, we discuss other levels of coregulation that may exist but remain largely unexplored, including mRNA modification and stability and posttranslational protein degradation.

中文翻译:


线粒体核调节的多个水平

核和线粒体基因组共同编码位于线粒体内膜上的氧化磷酸化(OXPHOS)复合物,并实现有氧生活。线粒体维持自己的基因组,该基因组由与其核对应物不同的因子表达和调控。为了获得最佳功能,细胞必须通过协调两个物理上分离且在进化上不同的基因表达系统,确保OXPHOS亚基的化学计量正确产生。在这里,我们主要在转录和翻译水平上回顾我们对微核共调节的当前理解。此外,我们讨论了可能存在但仍未充分探索的其他水平的调控,包括mRNA修饰和稳定性以及翻译后蛋白质降解。

更新日期:2018-11-26
down
wechat
bug