OBJECTIVE Suicide is the second leading cause of death among adolescents; however, objective biomarkers of suicide risk are lacking. Aberrant self-face amygdala activity is associated with suicide ideation, and its connectivity with neural regions that enable self-processing (eg medial prefrontal cortex) may be a suicide risk factor. METHOD Adolescents (aged 11-17 years; N = 120) were sorted into four groups: healthy controls (HC), depressed individuals with low suicide ideation (LS), depressed individuals with high suicide ideation (HS), and depressed suicide attempters (SA). Youth completed an emotional (Happy, Sad, Neutral) self-face recognition task in the scanner. Bilateral amygdala task-dependent functional connectivity was determined with psychophysiological interaction analysis. Connectivity was compared across groups and within Self versus Other faces across emotions and hemispheres. Voxelwise results were thresholded (p < .005, uncorrected) and corrected for multiple comparisons (p < .05, familywise error). RESULTS Both HS and SA displayed greater amygdala connectivity with the dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, and precuneus, compared to LS, who, in turn, showed greater connectivity than HC. Greater left amygdala-rostral anterior cingulate cortex (rACC) connectivity was observed in SA compared to all other groups, whereas right amygdala-rACC connectivity was greater in HS versus LS and HC. CONCLUSION Greater connectivity between amygdala and other regions implicated in self-face processing differentiated suicide ideation and suicide attempt groups. A dose-dependent response showed that greater rACC-left amygdala connectivity during self-face processing was associated with a recent suicide attempt, but that a greater rACC-right amygdala connectivity was associated with suicide ideation.

中文翻译：

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近期尝试自杀的抑郁青少年自我面孔处理过程中的杏仁核功能连接。

目的自杀是青少年中第二大死亡原因；自杀是青少年死亡的第二大原因。但是，缺乏自杀风险的客观生物标志物。异常的自我面孔杏仁核活动与自杀观念有关，并且其与能够自我加工的神经区域（例如内侧前额叶皮层）的连通性可能是自杀的危险因素。方法将青少年（11至17岁； N = 120）分为四组：健康对照组（HC），自杀意念低的抑郁者（LS），自杀意念高的抑郁者（HS）和自杀未遂者（ SA）。青年人在扫描仪中完成了情绪化的（开心，悲伤，中立）自我识别任务。双侧杏仁核任务依赖的功能连接性是通过心理生理学相互作用分析来确定的。在各个群体之间以及在情感和半球的“自我”与“其他”面孔中比较了连通性。对Voxelwise结果进行阈值化（p <.005，未校正），并针对多个比较进行校正（p <.05，家庭误差）。结果与LS相比，HS和SA与LS相比均显示出与背外侧前额叶皮层，背侧前额叶皮层和前胎的杏仁核连通性更高，而LS则比LS表现出更大的连通性。与所有其他组相比，在SA中观察到左杏仁核-前扣带回皮层（rACC）的连通性更高，而HS与LS和HC相比，右杏仁核-rACC的连通性更高。结论杏仁核与其他区域之间的更大连通性与自我面孔处理有关，从而区分了不同的自杀观念和自杀企图群体。