Transcriptomic profiling of tantalum metal implant osseointegration in osteopenic patients,BDJ Open

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Transcriptomic profiling of tantalum metal implant osseointegration in osteopenic patients
BDJ Open ( IF 2.5 ) Pub Date : 2018-11-23 , DOI: 10.1038/s41405-018-0004-6
E K Hefni ₁ , S Bencharit ₂ , S J Kim ₁ , K M Byrd ₁ , T Moreli ₁ , F H Nociti ₃ , S Offenbacher ₁ , S P Barros ₁

Affiliation

Objectives

The long-term success of dental implants is established by literature. Although clinically well defined, the complex genetic pathways underlying osseointegration have not yet been fully elucidated. Furthermore, patients with osteopenia/osteoporosis are considered to present as higher risk for implant failure. Porous tantalum trabecular metal (PTTM), an open-cell porous biomaterial, is suggested to present enhanced biocompatibility and osteoconductivity. The goal of this study was to evaluate the expression patterns of a panel of genes closely associated with osteogenesis and wound healing in osteopenic patients receiving either traditional titanium (Ti) or PTTM cylinders to assess the pathway of genes activation in the early phases of osseointegration.

Material and methods

Implant cylinders made of Ti and PTTM were placed in osteopenic volunteers. At 2- and 4 weeks of healing, one Ti and one PTTM cylinder were removed from each subject for RT-PCR analysis using osteogenesis PCR array.

Results

Compared to Ti, PTTM-associated bone displayed upregulation of bone matrix proteins, BMP/TGF tisuperfamily, soluble ligand and integrin receptors, growth factors, and collagen genes at one or both time points. Histologically, PTTM implants displayed more robust osteogenesis deposition and maturity when compared to Ti implants from the same patient.

Conclusions

Our results indicate that PTTM properties could induce an earlier activation of genes associated with osteogenesis in osteopenic patients suggesting that PTTM implants may attenuate the relative risk of placing dental implants in this population.

中文翻译：

骨质疏松患者钽金属种植体骨整合的转录组学分析

目标

种植牙的长期成功是有文献证实的。尽管临床上已明确定义，但骨整合背后的复杂遗传途径尚未完全阐明。此外，骨质减少/骨质疏松症患者被认为存在较高的种植失败风险。多孔钽小梁金属（PTTM）是一种开孔多孔生物材料，被认为具有增强的生物相容性和骨传导性。本研究的目的是评估接受传统钛 (Ti) 或 PTTM 圆柱体治疗的骨质减少患者中与成骨和伤口愈合密切相关的一组基因的表达模式，以评估骨整合早期阶段基因激活的途径。