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LC-MS-guided isolation of anti-inflammatory 2-(2-phenylethyl)chromone dimers from Chinese agarwood (Aquilaria sinensis)
Phytochemistry ( IF 3.8 ) Pub Date : 2019-02-01 , DOI: 10.1016/j.phytochem.2018.11.003 Hui-Xia Huo , Yu-Fan Gu , Zhi-Xiang Zhu , Yun-Feng Zhang , Xiao-Nan Chen , Peng-Wei Guan , She-Po Shi , Yue-Lin Song , Yun-Fang Zhao , Peng-Fei Tu , Jun Li
Phytochemistry ( IF 3.8 ) Pub Date : 2019-02-01 , DOI: 10.1016/j.phytochem.2018.11.003 Hui-Xia Huo , Yu-Fan Gu , Zhi-Xiang Zhu , Yun-Feng Zhang , Xiao-Nan Chen , Peng-Wei Guan , She-Po Shi , Yue-Lin Song , Yun-Fang Zhao , Peng-Fei Tu , Jun Li
Fifteen previously undescribed 2-(2-phenylethyl)chromone dimers, along with two known analogues were isolated from Chinese agarwood (Aquilaria sinensis) by a LC-MS-guided fractionation procedure. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The isolated compounds exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC50 values in the range 0.6-37.1 μM.
更新日期：2019-02-01
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