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Systematic review of association between critical errors in inhalation and health outcomes in asthma and COPD
npj Primary Care Respiratory Medicine ( IF 3.1 ) Pub Date : 2018-11-16 , DOI: 10.1038/s41533-018-0110-x
Janwillem W. H. Kocks , Henry Chrystyn , Job van der Palen , Mike Thomas , Louisa Yates , Sarah H. Landis , Maurice T. Driessen , Mugdha Gokhale , Raj Sharma , Mathieu Molimard

Inhaled medications are the cornerstone of treatment and management of asthma and COPD. However, inhaler device errors are common among patients and have been linked with reduced symptom control, an increased risk of exacerbations, and increased healthcare utilisation. These observations have prompted GINA (Global INitiative for Asthma) and GOLD (Global initiative for chronic Obstructive Lung Disease) to recommend regular assessment of inhaler technique in a bid to improve therapeutic outcomes. To better define the relationship between device errors and health outcomes (clinical outcomes, quality of life, and healthcare utilisation) in asthma and COPD, we conducted a systematic review of the literature, with a particular focus on the methods used to assess the relationship between device errors and outcomes. Sixteen studies were identified (12 in patients with asthma, one in patients with COPD, and three in both asthma and COPD) with varying study designs, endpoints, and patient populations. Most of the studies reported that inhalation errors were associated with worse disease outcomes in patients with asthma or COPD. Patients who had a reduction in errors over time had improved outcomes. These findings suggest that time invested by healthcare professionals is vital to improving inhalation technique in asthma and COPD patients to improve health outcomes.



中文翻译:

哮喘和COPD的吸入关键错误与健康结局之间的关联的系统评价

吸入药物是治疗和控制哮喘和COPD的基石。但是,吸入器设备错误在患者中很常见,并且与症状控制减少,病情加重的风险增加以及医疗保健利用增加有关。这些发现促使GINA(全球哮喘防治计划)和GOLD(全球慢性阻塞性肺疾病计划)建议定期评估吸入器技术,以改善治疗效果。为了更好地定义哮喘和COPD中设备错误与健康结局(临床结局,生活质量和医疗保健利用)之间的关系,我们对文献进行了系统的回顾,尤其侧重于评估两者之间关系的方法。设备错误和结果。鉴定了16项研究(不同的研究设计,终点和患者人群)(哮喘患者12例,COPD患者1例,哮喘和COPD均3例)。大多数研究报告说,哮喘或COPD患者的吸入错误与疾病恶化相关。随着时间的流逝减少错误的患者的结局得到改善。这些发现表明,医护人员投入的时间对于改善哮喘和COPD患者的吸入技术以改善健康状况至关重要。随着时间的流逝减少错误的患者的结局得到改善。这些发现表明,医护人员投入的时间对于改善哮喘和COPD患者的吸入技术以改善健康状况至关重要。随着时间的流逝减少错误的患者的结局得到改善。这些发现表明,医护人员投入的时间对于改善哮喘和COPD患者的吸入技术以改善健康状况至关重要。

更新日期:2019-11-18
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