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Theranostic nanosystems for targeted cancer therapy
Nano Today ( IF 13.2 ) Pub Date : 2018-12-01 , DOI: 10.1016/j.nantod.2018.11.001 Homan Kang 1 , Shuang Hu 1, 2 , Mi Hyeon Cho 3 , Suk Ho Hong 3 , Yongdoo Choi 3 , Hak Soo Choi 1
Nano Today ( IF 13.2 ) Pub Date : 2018-12-01 , DOI: 10.1016/j.nantod.2018.11.001 Homan Kang 1 , Shuang Hu 1, 2 , Mi Hyeon Cho 3 , Suk Ho Hong 3 , Yongdoo Choi 3 , Hak Soo Choi 1
Affiliation
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Nanomaterials have revolutionized cancer imaging, diagnosis, and treatment. Multifunctional nanoparticles in particular have been designed for targeted cancer therapy by modulating their physicochemical properties to be delivered to the target and activated by internal and/or external stimuli. This review will focus on the fundamental "chemical" design considerations of stimuli-responsive nanosystems to achieve favorable tumor targeting beyond biological barriers and, furthermore, enhance targeted cancer therapy. In addition, we will summarize innovative smart nanosystems responsive to external stimuli (e.g., light, magnetic field, ultrasound, and electric field) and internal stimuli in the tumor microenvironment (e.g., pH, enzyme, redox potential, and oxidative stress).
中文翻译：
用于靶向癌症治疗的治疗诊断纳米系统
纳米材料彻底改变了癌症成像、诊断和治疗。多功能纳米粒子尤其被设计用于靶向癌症治疗，通过调节其物理化学特性将其递送至目标并通过内部和/或外部刺激激活。本综述将重点关注刺激响应纳米系统的基本“化学”设计考虑因素，以实现超越生物屏障的有利肿瘤靶向，并进一步增强靶向癌症治疗。此外，我们还将总结对外部刺激（例如光、磁场、超声和电场）和肿瘤微环境中的内部刺激（例如pH、酶、氧化还原电位和氧化应激）做出响应的创新智能纳米系统。
更新日期：2018-12-01
中文翻译：
用于靶向癌症治疗的治疗诊断纳米系统
纳米材料彻底改变了癌症成像、诊断和治疗。多功能纳米粒子尤其被设计用于靶向癌症治疗，通过调节其物理化学特性将其递送至目标并通过内部和/或外部刺激激活。本综述将重点关注刺激响应纳米系统的基本“化学”设计考虑因素，以实现超越生物屏障的有利肿瘤靶向，并进一步增强靶向癌症治疗。此外，我们还将总结对外部刺激（例如光、磁场、超声和电场）和肿瘤微环境中的内部刺激（例如pH、酶、氧化还原电位和氧化应激）做出响应的创新智能纳米系统。
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