The Signaling Lymphocyte Activation Molecule family (SLAMF) is a collection of nine surface receptors expressed mainly on hematopoietic cells, and was found to modulate the behavior of immune cells. SLAMF receptors are expressed on B cells in health and disease. Each SLAM receptor has a unique differential expression pattern during the development and activation of B cells. Furthermore, recent findings have revealed a principal role for this family of receptors in B cell malignancies, emphasizing their importance in the control of malignant cell survival, cell to cell communication within the tumor microenvironment, retention in the supporting niches and regulation of T cell anti-tumor response. This review summarizes the latest studies regarding SLAMF expression and behavior in B cells and in B cell pathologies, and discusses the therapeutic potential of these receptors.

信号淋巴细胞激活分子家族（SLAMF）是主要在造血细胞上表达的九种表面受体的集合，并被发现可以调节免疫细胞的行为。在健康和疾病中，SLAMF受体在B细胞上表达。每个SLAM受体在B细胞的发育和激活过程中都有独特的差异表达模式。此外，最近的发现揭示了该受体家族在B细胞恶性肿瘤中的主要作用，强调了它们在控制恶性细胞存活，肿瘤微环境中的细胞间通信，在支持位中的保留和T细胞抗性的调节中的重要性。 -肿瘤反应。这篇综述总结了有关SLAMF在B细胞和B细胞病理学中的表达和行为的最新研究，