WD40 repeat and FYVE domain containing 3 (WDFY3) is an adaptor protein involved in selective degradation of protein aggregates by autophagy. Recent studies have revealed that Wdfy3 is critical in the regulation of brain development and osteoclastogenesis in vivo. However, the function of Wdfy3 in cardiac development remains completely unknown. In this study, we explore the role of Wdfy3 in cardiac morphogenesis using Wdfy3-deficient mice.

中文翻译：

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WD40重复序列和含有3个FYVE结构域对于心脏发育至关重要。

WD40重复序列和包含FYVE结构域的3（WDFY3）是一种衔接蛋白，参与通过自噬选择性降解蛋白质聚集体。最近的研究表明，Wdfy3在体内调节大脑发育和破骨细胞形成中至关重要。但是，Wdfy3在心脏发育中的功能仍然完全未知。在这项研究中，我们探索Wdfy3在使用Wdfy3缺陷小鼠的心脏形态发生中的作用。