We read with great interest the article by van den Hoogen et al 1 describing galectin-9 (Gal-9) as a novel, easy-to-measure biomarker for the interferon (IFN) signature in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). We support the views expressed by the authors that IFN signature is an important biomarker in disease activity in SLE and there is certainly a need for easier to measure biomarkers for IFN signature, but to suggest that Gal-9 could aid in clinical decision making in steering anti-IFN therapy seems premature. We know that the common …

中文翻译：

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生物标志物：成为或不成为

我们非常感兴趣地阅读了 van den Hoogen 等人 1 的文章，该文章描述了半乳糖凝集素 9 (Gal-9) 作为系统性红斑狼疮 (SLE) 和抗磷脂综合征中干扰素 (IFN) 特征的一种新型、易于测量的生物标志物(APS)。我们支持作者表达的观点，即 IFN 特征是 SLE 疾病活动的重要生物标志物，当然需要更容易测量 IFN 特征的生物标志物，但建议 Gal-9 可以帮助指导临床决策抗干扰素治疗似乎为时过早。我们知道，常见的…