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Design and investigation of ytterbium tungstate nanoparticles: An efficient catalyst for the sensitive and selective electrochemical detection of antipsychotic drug chlorpromazine
Journal of the Taiwan Institute of Chemical Engineers ( IF 5.5 ) Pub Date : 2018-11-10 , DOI: 10.1016/j.jtice.2018.10.021
Periyasamy Sundaresan , Alagumalai Krishnapandi , Shen-Ming Chen

In this work, we have developed ytterbium tungstate (Yb2WO6) as an electrocatalyst through a simple co-precipitation method. The as-prepared catalyst was systematically investigated by various characterization techniques such as X-ray diffraction (XRD), Raman spectroscopy, field emission-scanning electron microscopy (FE-SEM) and energy-dispersive X-ray analysis (EDX). The as-developed Yb2WO6 was successfully applied to the electrochemical sensor (electrocatalyst) for sensitive and selective detection of antipsychotic drug chlorpromazine (CPZ). Interestingly, the Yb2WO6 modified screen printed carbon electrode (Yb2WO6/SPCE) shows an excellent electrocatalytic activity towards CPZ with extented wide linear response range and lower detection limit of 0.01–2520 µM and 0.001 µM, respectively. Moreover, the as-developed Yb2WO6/SPCE delivered an excellent selectivity even in the existence of cation, anion and some biologically co-interfering compounds. Furthermore, the Yb2WO6/SPCE displays an appreciable stability, and repeatability towards CPZ sensing. In addition, the Yb2WO6/SPCE was successfully applied to real sample analysis in CPZ tablet and urine samples with acceptable recoveries.



中文翻译:

钨酸nanoparticles纳米颗粒的设计和研究:灵敏和选择性电化学检测抗精神病药物氯丙嗪的有效催化剂

在这项工作中,我们通过简单的共沉淀方法开发了钨酸Y(Yb 2 WO 6)作为电催化剂。通过各种表征技术,如X射线衍射(XRD),拉曼光谱,场发射扫描电子显微镜(FE-SEM)和能量色散X射线分析(EDX),对制得的催化剂进行了系统的研究。已开发的Yb 2 WO 6已成功应用于电化学传感器(电催化剂),用于灵敏和选择性地检测抗精神病药物氯丙嗪(CPZ)。有趣的是,Yb 2 WO 6改性丝网印刷碳电极(Yb 2 WO 6/ SPCE)对CPZ表现出优异的电催化活性,线性响应范围广,检出限分别下限0.01–2520 µM和0.001 µM。而且,即使存在阳离子,阴离子和一些生物共干扰化合物,如此发展的Yb 2 WO 6 / SPCE仍具有出色的选择性。此外,Yb 2 WO 6 / SPCE显示出可观的稳定性和对CPZ感测的可重复性。此外,Yb 2 WO 6 / SPCE已成功应用于CPZ片剂和尿液样品中的真实样品分析,回收率令人满意。

更新日期:2019-03-12
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