Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease characterized by a breakdown in immune tolerance leading to the development of auto-reactive lymphocytes and autoantibodies. Recent findings have provided new insight on the role of the signaling lymphocytic activation molecule family (SLAMF) receptors, a group of nine co-regulatory molecules involved in the activation of hematopoietic cells, and their downstream protein SLAM-associated protein (SAP), into the pathogenesis of SLE. This review summarizes the current knowledge on SLAMF in human SLE immunopathogenesis, and the importance of SLAMF molecules as new therapeutic targets.

系统性红斑狼疮（SLE）是一种多因素自身免疫性疾病，其特征是免疫耐受性下降，导致自身反应性淋巴细胞和自身抗体的发展。最新发现为信号转导淋巴细胞激活分子家族（SLAMF）受体，参与造血细胞激活的九种共调节分子及其下游蛋白SLAM相关蛋白（SAP）的作用提供了新的见解。 SLE的发病机制。这篇综述总结了人类SLE免疫发病机制中SLAMF的最新知识，以及SLAMF分子作为新治疗靶标的重要性。